Lipodrene Review: Original Thermogenic Fat Burner (Updated 2025)

📖 Table of Contents

• What Is Lipodrene With Ephedra
• Formula Timeline
• How Does It Work
• Is Lipodrene Banned / Lipodrene Recall
• Lipodrene Ingredients
• What Are The Benefits
• Lipodrene Reviews
• Stacks
• Alternatives To Lipodrene
• Where To Buy
• Side Effects And Warnings
• Disclaimer

If you’ve been in the bodybuilding or fitness world for a while, chances are you’ve heard the name Lipodrene® with Ephedra—aka the original thermogenic fat burner that put Hi-Tech Pharmaceuticals on the map. But like most legends, Lipodrene has evolved. While it still packs the fat-burning punch it’s famous for, today’s formula reflects updated ingredients, new stimulant technology, and more refined delivery. In this post, we’ll break down what’s changed, what hasn’t, what users are saying now, and whether Lipodrene still lives up to the hype.

What is Lipodrene?

Lipodrene with ephedra by Hi-Tech Pharmaceuticals is a high-stimulant thermogenic fat burner designed to support fat loss, appetite suppression, and clean energy. But it’s more than just a stimulant—Lipodrene features a 3-way fat-burning system intended to help you:

• Burn calories and target stubborn fat†
• Help control sugar cravings†
• Suppress appetite for better diet control†

Since its introduction, Lipodrene has become one of the most widely recognized and best-selling fat burners in the industry. With over a billion tablets sold in the U.S. alone, it has maintained a strong presence among athletes, bodybuilders, and everyday users looking for fast-acting fat-loss support.†

Lipodrene’s Formula Timeline

Like other popular products from Hi-Tech Pharmaceuticals, Lipodrene has evolved over the years due to both innovation and regulatory changes.† Here’s how it developed:

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2000s-2017: The DMAA Legacy

Notable ingredients in the original version included:

• Ephedra Extract
• Acacia Rigidula Extract
• Phenylethylamine Alkaloids (150mg total)
• B-Phenylethylamine / R-Beta-Phenylethylamine / Phenylethylamine HCL
• 1,3-Dimethylamylamine HCL (DMAA)

However, by mid-2017, this version was discontinued due to FDA enforcement against DMAA and certain synthetic alkaloids. Still, it left a legacy that users continue to remember as one of the most potent fat burners ever created.†

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2018–Present: The DMHA & Senegalia Reformulation

In response to regulatory changes, Hi-Tech Pharmaceuticals reformulated Lipodrene in 2018 to maintain its effectiveness while removing DMAA. The newer formula introduced DMHA analogs and updated plant alkaloids to replicate the stimulant power of the original.†

New and updated ingredients include:

• Senegalia Berlandieri Extract: A natural stimulant source with PEA alkaloids, similar to Acacia Rigidula but more widely accepted. Supports energy, euphoria, and appetite control.†
• Phenylethylamine Alkaloids: Increased to 225mg, supporting mood, focus, and thermogenesis.†
• N, N-Dimethylphenethylamine: A modern analog of PEA that supports energy and cognitive performance.†
• Theophylline: A methylxanthine that increases cAMP levels, enhancing fat oxidation, heart rate, and breathing capacity during workouts.†
• Yohimbine: Added to help release stubborn fat and intensify thermogenesis.†

Together, these ingredients created a new Lipodrene—powerful, legal, and compliant. While some longtime users noticed a slight difference in stimulation compared to the DMAA version, most agreed the effects were still intense, consistent, and highly effective for appetite suppression, focus, and fat burning.†

How Does Lipodrene® Work?

Lipodrene® with Ephedra is a thermogenic fat burner designed to help you lose weight by boosting metabolism, curbing hunger, and providing sustained energy, making it effective for both beginners and experienced users.†

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What Is Thermogenesis?

Thermogenesis refers to your body’s production of heat. When you take a thermogenic supplement like Lipodrene, it increases your basal metabolic rate (the calories burned at rest), which in turn triggers more calories—especially from fat stores—to be burned off. (1)

Studies show combinations like ephedrine (or ephedra extract) and caffeine can increase metabolic rate significantly—up to 8% over a few hours—resulting in meaningful fat loss when used consistently.† 

Why the Combination Matters

• Increased calorie burn: By speeding up your metabolism, Lipodrene helps your body burn more calories throughout the day, even when you’re inactive.†
• Fat utilization: The increased energy demand encourages your body to tap into stored fat as fuel.†
• BMR support: A higher basal metabolic rate helps maintain weight loss over time by reducing the chances of calorie storage.†

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What This Means for You

If you’re new to fat burners, Lipodrene can provide a helpful edge by boosting both energy and calorie burn. For experienced users, it offers a consistent thermogenic effect to match calorie control and exercise.†

Here’s what you can expect in your daily routine:

1. More energy: You’ll likely feel more alert, especially during morning workouts or busy days.†
2. Fat-burning efficiency: Your body is encouraged to use stored fat, especially in stubborn areas, as an energy source.†
3. Support for diet efforts: Less hunger and better calorie utilization help you stay on track with nutrition goals.†

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Tips for New Users

• Start with one tablet in the morning to evaluate tolerance before considering a full dose.†
• Avoid taking Lipodrene late in the day to prevent sleep disruption.†
• Stay hydrated—thermogenesis and caffeine can increase water loss.†
• Combine with a healthy diet and exercise for best results—thermogenics support, they don’t replace, a lifestyle plan.†

Is Lipodrene Banned/Lipodrene Recall?

No, Lipodrene is not banned. However, certain professions or customs regulations might have their own restrictions. If you have concerns about its use in your profession or for importation purposes, we recommend contacting your employer or customs office for more information.

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A Brief History of Lipodrene:

While Lipodrene is not currently banned, it has faced some challenges. Like many other fat burners, it initially contained DMAA, a powerful stimulant banned by the FDA around 2016. Afterward, it was reformulated to include DMHA, a similar stimulant that is still allowed in dietary supplements today.

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Recalls and Safety:

Over the past 15 years, Lipodrene has been recalled a few times, mainly involving specific batches rather than the entire product line. The major reformulation occurred in 2017, when DMAA was replaced with DMHA.

One notable recall occurred on May 12, 2021, due to the presence of DMAA in a specific batch (Lot #001211197, Exp. 12/25). DMAA is known for potential cardiovascular risks such as elevated blood pressure, irregular heartbeats, and heart attacks. The FDA considers DMAA unsafe, and products containing it are illegal as dietary supplements.

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Current Status:

As of 2025, Lipodrene has no ongoing production delays. Past delays affected several fat burners, including Hydroxyelite, Lipodrene Elite, Hardcore, Xtreme, Hellfire, and Black Mamba.

In summary, Lipodrene is not banned and remains a legal and safe product as long as you follow the directions.

With all that said, let’s dive into these ingredients!

The Ingredient Breakdown:

Lipodrene uses a 560 mg proprietary blend, which means the total is disclosed, but individual ingredient amounts are not. However, understanding each class of ingredient can help you determine how Lipodrene works and whether it aligns with your goals.†

 

 

Caffeine (100mg)

Anhydrous caffeine is a fast-acting stimulant that boosts alertness, enhances workout performance, and increases calorie burning. It also helps suppress appetite, making it a reliable support for fat loss†. Even modest doses—like one cup of coffee—can elevate metabolism by 3–4% for a few hours. (2)

The amount in Lipodrene is enough to promote clean, noticeable energy, without overwhelming most users.†

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The Proprietary Blend:

Keep in mind: many ingredients serve multiple functions, including fat burning, appetite control, mood support, and cognitive enhancement. What works best for you may depend on your tolerance, metabolism, and goals.†

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Heavy Stimulants:

These are the power players in Lipodrene’s blend—ideal for experienced users looking for strong energy, thermogenesis, and appetite suppression.

1. Ephedra Extract (25mg)

Once related to the now-banned ephedrine, ephedra extract still packs a serious punch.† It’s best known for:

• Supporting energy and alertness†
• Promoting appetite suppression†
• Enhancing metabolism and fat oxidation†

While not ephedrine, ephedra shares many of its stimulating effects, and is legal in its current herbal form. (3) To read more on what separates ephedra from ephedrine, click here.

2. 2-Aminoisoheptane HCl (DMHA)

A potent stimulant also known as Octodrine, DMHA is included to:

• Sharpen focus and motivation†
• Enhance energy output†
• Support thermogenesis†
• Offer mood-elevating effects†

DMHA works similarly to DMAA and is often found in high-powered pre-workouts and advanced fat burners. (4)

3. Synephrine HCl & Citrus Aurantium Extract

These work together to mimic adrenaline in the body, increasing:

• Calorie burn†
• Energy (without major spikes in blood pressure)†
• Appetite control Synephrine is often called the “safe alternative to ephedrine,” and Citrus Aurantium provides natural p-synephrine to support these effects.† (5,6)

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Other Stimulants:

These offer milder support, helping round out the energy profile without overwhelming your system.†

4. Theobromine

Naturally found in cocoa, theobromine is like a cousin to caffeine but gentler. (7)  It may:

• Increase energy and mental clarity†
• Help shed excess water weight†
• Support mild appetite suppression†

5. Green Tea Extract

Rich in EGCG and polyphenols, this well-known compound may: (8)

• Support fat metabolism†
• Improve antioxidant activity†
• Work synergistically with caffeine†

6. Yohimbine HCl

A fast-acting stimulant that divides users—you either love it or leave it.† When it works for you, it’s powerful: (9,10)

• Blocks alpha-2 receptors on fat cells, allowing fat to mobilize and burn off more easily†
• May increase adrenaline and energy†
• Offers strong appetite control for some users†

⚠️ Note: Sensitive users may feel jittery or anxious from Yohimbine, so assessing tolerance is best.†

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Appetite Suppression & Metabolic Enhancers:

Beyond stimulants, Lipodrene includes several ingredients that may support weight loss in more indirect ways.

7. Hoodia Extract

Sourced from the Hoodia Gordonii plant of southern Africa, this traditional appetite suppressant has been used by tribes to survive long hunts. Clinical data is still evolving, but it remains a popular natural ingredient.† (11)

8. Cassia Nomame Extract

Believed to act as a lipase inhibitor, this plant-based extract may: (12)

• Reduce fat absorption from the diet†
• Promote fat excretion, reducing overall calorie intake†

9. Naringen

A flavonoid found in grapefruit, naringen may: (13,14)

• Support thermogenesis†
• Stimulate adiponectin, a fat-burning hormone†
• Boost the effects of other stimulants like synephrine†

10. 6,7-Dihydroxybergamottin 

Also derived from grapefruit, this compound is thought to: (15)

• Slow down the metabolism of certain ingredients†
• Prolong and intensify the effects of stimulants† (This is why grapefruit juice is often avoided with medications—it can enhance their effects.)

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Mood Boosting:

A dieting supplement isn’t just about fat burning—it’s also about helping you feel good while doing it. That’s where these ingredients come in. (16,17)

11. L-5-Hydroxytryptophan (5-HTP)

A precursor to serotonin, 5-HTP may: (16,17)

• Improve mood and emotional balance†
• Help manage cravings, especially for carbs†
• Support overall well-being†

12. 5-Methoxytryptamine HCl (5-MT) 

Less common than 5-HTP, this compound is a precursor to melatonin. In Lipodrene, it may: (18)

• Offer antioxidant and neuroprotective effects†
• Regulate biological rhythms†
• Support serotonin pathways without causing sleepiness†
• Due to the strong stimulant base, its relaxing effects are likely offset. (19)

How to take Lipodrene?

Lipodrene with Ephedra’s instructions states to take 1-2 tablets in the morning and one tablet after lunch. They also warn people not to exceed four tablets daily.

Recommended Dose

• Start with one tablet on an empty stomach in the morning to assess your tolerance.
• If well tolerated, increase to 1–2 tablets in the morning plus one tablet after lunch, for up to 4 tablets daily.

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Usage Timing

• Space doses at least 6 hours apart to honor the daily 4-tablet limit.
• Avoid taking tablets late in the afternoon to reduce the risk of sleep problems—Lipodrene’s stimulants can last up to 6 hours.
• If you’re caffeine- or stimulant-sensitive, skip the afternoon dose entirely.

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Cycling

• Do not use for more than eight continuous weeks. Take a 4–6 week break before resuming to avoid tolerance and overstressing your system.
• This cycle length aligns with Hi-Tech’s classical guidelines and user-reported best practices.

Who Should Try Lipodrene with Ephedra?

Lipodrene is a powerful thermogenic fat burner designed for individuals who want to support weight loss, energy, and focus. Despite its reputation for potency, it can be suitable for a wide range of users, provided you take a thoughtful, well-informed approach.

Ideal For:

• First-time stimulant users: You can start with a low dose—just 1 tablet in the morning—and gradually increase as tolerance builds. This flexibility makes it approachable even if you’re sensitive.†
• Intermediate to advanced users: If you’re accustomed to stimulants like coffee, pre-workouts, or other fat burners, Lipodrene can offer a reliable next level of energy and fat-burning support. †
• Plateau breakers: Many users report powerful but smooth energy, extended focus, and appetite control—key tools for breaking through weight-loss or training plateaus.†
• Anyone needing mental or workout support: With ingredients that support mood, alertness, and satiety, Lipodrene functions almost like a smart pre-workout†

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Why It Works for Different Users

• Adaptable dosing: You can tailor the experience to 1 tablet in the morning for minimal boost and up to 3 tablets for more aggressive results.†
• Smooth energy: User feedback consistently describes long-lasting energy with little crash, a benefit for beginners to experienced users.†
• Mood and focus enhancement: PEA and synergy of ingredients help maintain motivation and mental clarity when you’re dieting or training hard.†

 Lipodrene Benefits & FAQs:

Lipodrene with Ephedra is a powerful, stimulant-driven fat burner, so the most noticeable effects are energy boosts and appetite suppression. That said, users also report mood improvements and reliable weight loss. † Individual results vary, but here’s a breakdown of what you can generally expect:

• Increased Energy: Many users describe a clean, sustained energy boost ideal for workouts or busy days, with minimal jitters or crashes.†
• Appetite Control: A strong appetite suppressant blend helps manage cravings and supports calorie control, though effects may vary depending on individual response.†
• Improved Mood: Ingredients like phenylethylamine analogs, 5‑HTP, and 5‑MT often result in a mild mood lift and enhanced motivation.†
• Weight Loss: Thermogenic and fat-mobilizing compounds help support fat reduction when used alongside proper diet and training.†

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Frequently Asked Questions

How Long Does the Energy Last?
Most users feel energized for 4–6 hours after taking Lipodrene—enough for workouts or busy days.†
Will I Experience a Crash?
Rarely. Users frequently describe Lipodrene’s energy as smooth and fading gradually rather than abruptly.†
Can It Improve Mood and Focus?
Yes. Many users report boosted mental clarity and motivation, thanks to mood-enhancing ingredients like 5-HTP and 5-MT.†
How Much Weight Can I Expect to Lose?
Studies on ephedra + caffeine suggest around 2 lbs/month of additional fat loss versus placebo when paired with diet and exercise.†
Is Appetite Suppression Strong?
It’s effective for many, especially when paired with structured, calorie-controlled meals.†
Is Lipodrene Beginner-Friendly?
Yes—if you start slowly. A single morning tablet is ideal to assess tolerance before progressing to higher doses.†

Lipodrene Reviews:

Customer Review By Corina: “I’ve lost a total of 10lbs in 1 1/2 months of using this product!! Definitely works!”

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Customer Review By Jay: “It says take 1 or 2. Don’t take 2. It’ll make you very jittery and uncomfortable for hours. But one before the workout and one after keeps me rolling all day. Not bad. I wish it was real ephedra and not the “green ephedra” or Mormon Tea as they call it. It’s not bad though.”

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Customer Review By Kerry: “I’ve been taking Lipodrene for 2 months now and I must say it’s highly effective from the appetite suppressant to the long-lasting energy! Highly recommend!”

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Customer Review By Karen: “Lipodrene gives me the energy and focus I need to power through my day! It helps control my appetite without the jitters, and I’ve noticed a real difference in my workouts and weight loss. Definitely my go-to!”

Stacking With Lipodrene:

Lipodrene is a versatile fat burner that can be effectively combined with other supplements to create powerful stacks to support your weight loss goals. Here are some of the top Lipodrene-based stacks that pair Hi-Tech Pharmaceuticals’ renowned fat burner with other potent products to enhance your journey toward achieving a leaner physique.

• Slimaglutide Burner Stack
• Lipodrene Weight Loss Stack
• Lipodrene Before and After Boost Kit
• Lipodrene Keto Lean Stack

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Slimaglutide Burner Stack:

How It Works:
Select your preferred fat burner from Hi-Tech Pharmaceuticals’ elite lineup, such as Lipodrene or Hellfire. These products are designed to increase thermogenesis, helping to burn calories, while Slimaglutide synergistically supports metabolism. Together, they form a powerful duo for tackling weight loss.†

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The SlimBurner Stack Benefits:

• Maximized Thermogenesis: Accelerate fat burning with your chosen fat burner, supported by Slimaglutide’s metabolic enhancement.†
• Appetite Control: Keep cravings in check, reducing the urge to overeat.†
• Energy Boost: High energy for your workouts from the fat burner, complemented by the sustained energy from Slimaglutide.†
• Multifaceted Weight Management: Slimaglutide’s GLP-1 and GIP support may help in long-term weight management success.†

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How To Take The Slimaglutide Burner Stack:

• Lipodrene:  Take 1-2 tablets in the morning and one tablet after lunch. Test tolerance first by taking only one tablet a day.
• Slimaglutide: Take three (3) tablets with 4 ounces or less of water twice daily on an empty stomach. Take the first dose in the morning and the second dose in the afternoon.

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Lipodrene Weight Loss Stack:

How It Works:
This stack pairs Lipodrene’s thermogenic power with Carnislim’s unique Carnitine compounds for enhanced fat metabolism and energy support, while CLA 1000 helps with lean muscle development and body composition.†

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The Lipodrene Weight Loss Stack Benefits:

• Fat Metabolism: Lipodrene and Carnislim work together to boost fat burning while maintaining energy levels.†
• Lean Muscle Support: CLA 1000 encourages lean muscle development, helping burn fat more efficiently.†
• Performance Enhancement: Carnislim’s 5 Carnitine compounds fuel high-energy organs like the heart, brain, and liver, improving overall endurance and physical performance.†

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How To Take The Weight Loss Stack:

• Lipodrene:  Take 1-2 tablets in the morning and one tablet after lunch. Test tolerance first by taking only one tablet a day.
• Carnislim: Take two tablets of Carnislim twice a day, 8-12 hours apart.
• CLA: Take two softgels of CLA 1000 three times a day with food (breakfast, Lunch, and Dinner).

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Lipodrene Before and After Boost Kit:

How It Works:
This stack combines the fat-burning power of Lipodrene with Laxogenin’s anabolic properties to help you shed fat while building or maintaining lean muscle mass. It’s an ideal transformation stack for individuals looking to achieve a visible before-and-after physique.†

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The Lipodrene Before and After Boost Kit Benefits:

• Weight Loss: Lipodrene’s potent ingredients, like ephedra and caffeine, boost metabolism and fat loss.†
• Strength Enhancement: Laxogenin helps increase protein synthesis, supporting muscle growth and strength during fat loss.†

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How To Take the Before and After Kit:

• Lipodrene: Take 1-2 tablets in the morning and 1 tablet after lunch. Test tolerance first by taking only 1 tablet a day.
• Laxogenin 100: Take 2 tablets daily (AM/PM Split).

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Lipodrene Keto Lean Stack:

How It Works:
For those on a keto diet, the Lipodrene Keto Lean Stack offers fat-burning support while maintaining ketosis. Lipodrene provides thermogenesis and energy, while Keto Lean enhances fat metabolism by boosting the body’s ability to use fat as fuel.†

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The Lipodrene Keto Lean Stack Benefits:

• Fat-Burning Efficiency: Lipodrene targets stubborn fat while Keto Lean ensures your body efficiently burns fat for energy.†
• Keto Support: Keto Lean helps optimize ketosis and supports energy levels, ensuring you stay on track with your ketogenic lifestyle.†

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How To Take the Keto Lean Stack:

• Lipodrene: Take 1-2 tablets in the morning and 1 tablet after lunch. Test tolerance first by taking only 1 tablet a day.
• Keto Lean: Take 3 capsules daily. Do not exceed 6 capsules per day.

Lipodrene Alternatives:

Finding the right fat burner can be a journey, especially if you’re not sure Lipodrene with Ephedra is the right match. Fortunately, there are several potent thermogenic options available that offer comparable or unique benefits. Below, we’ve broken down the top alternatives based on key ingredients, energy level, and best fit for your goals.

Looking for Lipodrene variants like Lipodrene Hardcore or  Lipodrene Xtreme V2? [Read our Lipodrene Versions Comparison Blog] for full breakdowns. This section focuses on alternatives from other brands.

Where To Buy Lipodrene?

Looking to get started—or ready for your next round? You can order Lipodrene and Lipodrene stacks directly from SameDaySupplements.com, where they’re in stock and ready to ship fast.

• Ships same day (M–F before 3 PM EST)
• Trusted U.S. retailer with verified customer reviews
• Bundle deals available with CLA, Carnitine, Slimaglutide, and more

Whether you’re after clean energy, appetite support, or enhanced thermogenesis, we’ve got your fat burner, locked and loaded.†

Wrapping Up!

And this marks the end of our post on Lipodrene with Ephedra. Thank you for reading! And as always, if there was something that wasn’t clear, another question you might have, or if you have another idea for a blog, Email Us!

Want to read how Lipodrene with Ephedra compares to other popular fat burners? Check out our other blogs below!

• Hydroxyelite VS Lipodrene
• Hellfire VS Lipodrene
• Stimerex ES VS Lipodrene

Side Effects and Warnings:

Read the entire label before taking this product. Not for use by individuals under the age of 18 years. Do not use if you are pregnant or nursing. Individuals who consume caffeine with this product may experience serious adverse health effects. People who are sensitive to caffeine should consult a doctor before using it. Do not consume synephrine or caffeine from other sources, including but not limited to:

• Coffee
• Tea
• Soda
• other dietary products
• Medications containing caffeine or phenylephrine

Consult with your physician before use if you are taking medication, including but not limited to:

• MAOI inhibitors
• Aspirin
• Antidepressants
• Non-steroidal anti-inflammatory drugs
• Products containing phenylephrine, ephedrine, pseudo-ephedrine, or other stimulants

Consult your physician before use if you have a medical condition, including but not limited to:

• Heart, liver, kidney, or thyroid disease
• Psychiatric or epileptic disorders
• Difficulty urinating
• Diabetes
• High blood pressure
• Cardiac arrhythmia
• Recurrent headaches
• Enlarged prostate
• Glaucoma

Stop 2 weeks before surgery or if you experience:

• Rapid heartbeat
• Dizziness
• Severe headache
• Shortness of breath

In case of accidental overdose, seek professional assistance or contact a poison control center immediately. Exceeding recommended serving may cause serious adverse health effects, including heart attack and stroke. Improper use of this product may be hazardous to a person’s health.

This product should not be used in place of or as a substitute for recommendations by your healthcare professional. No clinical study has been performed on Lipodrene®.

These statements are based upon the active ingredients:

• Senegalia Berlandieri
• Ephedra
• Theobromine
• Yohimbe
• Citrus aurantium
• Caffeine
• Green tea
• 5-HTP
• 5-methoxytryptamine
• Phenylethylamine

This product can raise your blood pressure and interfere with other drugs you may be taking. Talk to your doctor about this product.

This product contains ingredients that may be banned by some sports organizations and/or increase the risk of a false positive on a drug test. Please consult with your sport organization or physician before taking this product.

Disclaimer:

†PLEASE NOTE: The intention of the information provided is for reference only. Furthermore, we are in no way providing medical advice or instruction. Instead, the information provided in this guide/blog utilizes anecdotal information and available studies/reviews. While our goal is to maintain and display accurate information, we can’t guarantee it represents the latest formulation of the product or information. Therefore, please visit the manufacturer’s website if you have any concerns. Also, the information above does not represent our views here at Same Day Supplements. Instead, these are the manufacturers’ and users’ views and information. The Food and Drug Administration has not evaluated these statements. Finally, these products aim not to diagnose, treat, cure, or prevent any disease or illness.