Lipodrene with Ephedra | Supp Spotlight Review

Lipodrene with Ephedra | Supplement Spotlight

What is Lipodrene? Lipodrene with ephedra, by Hi-Tech Pharmaceuticals, is a thermogenic weight loss product. It contains a 3-way fat burning system that has made lipodrene one of the top selling fat burners in America. This fat burning system is aimed to help you: burn away calories and fat, help control sugar cravings, and suppress your appetite.

More than 15 years after it’s introduction, there have been over a billion tablets of lipodrene sold. If you’ve tried lipodrene in the past (prior to 2018), you may notice some changes. For more information on what’s different check out our blog on the Old Version vs The New.

lipodrene with ephedra energy expenditure

How Does It Work?

Before we get into the ingredient break down, lets go over what lipodrene is meant to do. As we previously mentioned it’s a thermogenic.

A thermogenic supplement is something (containing natural ingredients) with the purpose of increasing your metabolism. This is done by helping your body burn more calories. When you’re body is burning calories, it generates more heat(1).

This process helps increase weight loss by increasing the efficiency that your body burns these calories (energy expenditure) through your metabolism. Increasing your metabolism ultimately means that your body will use the calories from the food you eat instead of storing them as fat.

The Breakdown:

Now lets go over how lipodrene with ephedra accomplishes this. Like most fat burners, lipodrene contains a proprietary blend. This means that instead of given the milligrams of each ingredient in the blend, they disclose the total amount of milligrams for the blend.

lipodrene with ephedra label

In total, lipodrene contains 660 milligrams of active ingredients. Caffeine takes 100 mgs and the proprietary blend is the other 560 mgs.


This is a stimulant that interacts with your central nervous system or your CNS. This will help you feel more alert and give you a boost of energy.Caffeine is a good base stimulant that sets the foundation for the more exotic stimulants.

Including caffeine in a fat burner can also positively influence your metabolism (2). This can result in experiencing some appetite suppression in addition to energy.†

lipodrene with ephedra prop blend

The Proprietary Blend

The proprietary blend contains the bulk of ingredients. To help organize the label, we’ll break the ingredients into different categorizes. However it is important to note that ingredients have multiple purposes. So just because we sectioned an ingredient as an appetite suppressant, doesn’t mean it doesn’t serve as a stimulant (or another purpose) as well.

With any stimulant, including caffeine, there will be some degree of appetite suppression and focus properties. Yet, it is not always experienced for every individual. This is just because we are all different, and our bodies react to products differently.

lipodrene with ephedra hard hitter

Heavy Stimulants

A popular stimulant many years ago (prior to ~2002) was ephedrine. This herb promoted weight loss by means of increasing your metabolism. But this ingredient is no longer available in dietary supplements. Now supplements contain the alkaloid ephedra. Despite not being the exact same compound, ephedra exerts very similar effects. Including the effects on weight loss (3).

To read more on what separates ephedra from ephedrine click here. Ephedra is most notably recognized for it’s effects on increasing energy and suppressing appetite.

The next heavy stimulant in the label is senegalia berlandieri. Unlike ephedra, and most of the other stimulants in lipodrene, senegalia berlandieri crosses supplement platforms.

Meaning it’s a prominent ingredient in fat burners, as well as pre workouts. This is because senegalia berlandieri is an effective stimulant with added benefits from the phenylethylamine alkaloids it yields(4). Which promotes focus and even some mood boosting properties.

Following the phenylethylamine alkaloids, is synephrine HCl. Synephrine HCl is an ingredient similar to ephedrine. This stimulant is also a strong appetite suppressant.

Synephrine works by acting like natural adrenaline when ingested. This helps increase metabolism and boost energy without increasing blood pressure(5).

Skipping down the label, we also have theophylline for our heavy stimulant category. Theophylline is stimulant with bronchodilating properties. This means that theophylline is effective for treating conditions like asthma.

In terms of weight loss, theophylline was shown to be as effective as ephedrine in a study on weight loss and resting energy expenditure(6).

lipodrene with ephedra energy

Other Stimulants

The following ingredients contain stimulate properties but are not as strong as the ones above. This of course is subjective, but we find (from customer feedback and data on scientific studies) that these ingredients are not as stimulating.

Our first ingredient in this category is theobromine. Theobromine, like caffeine, is a naturally occurring compound found in cacao plants and tea leaves. Since it is a stimulant, it provides energy and may help shed water weight. Like other stimulants, theobromine also has appetite suppressing properties (7).

Another stimulant found in tea leaves is Green tea extract. Green tea is rich in polyphenol catechins and caffeine. The combination of these compounds may increase weight loss, though there is still more research needed to be certain(8).

Our last stimulant is also the last ingredient on the label, Yohimbine HCl. This ingredient is usually a hit or miss for people. Some people love it and take it on it’s own and some try to stay away from it. However no matter where you stand on yohimbine one thing is clear, it is effective.

Yohimbine is a mild stimulant and can help suppress appetite, but there’s more to its fat-burning properties. The main way that yohimbe works in the body is through blocking alpha-2 adrenergic receptors located in fat cells. Once yohimbine has bound with a fat cell, it “turns off” the alpha receptor, which allows the fat cells to mobilize and burn off(9,10).

lipodrene with ephedra appetite suppression

Appetite Suppression

Now that we have gone though the stimulants in Lipodrene with ephedra, lets go over the other ingredients that set it apart.

As previously mentioned all stimulants in this formula will have appetite suppressing properties, but not all appetite suppressing ingredients are a stimulant. In lipodrene with ephedra this non-stim ingredient is Hoodia Extract.

Hoodia extract is from the hoodia gordoni plant that grows in the Kalahari Desert of southern Africa. Although hoodia extract is a popular appetite suppressant, more scientific data will be needed to conclude its effects(11).

lipodrene with ephedra mood boosting

Mood Boosting

A prominent feature in fat burners is the addition of mood boosting ingredients. These ingredients generally provide a feeling of euphoria and can also aid in focus.† In lipodrene’s case this includes 5-Methoxytryptamine HCl and L-5-Hydroxytryptophan or 5-MT and 5-HTP. Both 5-MT and 5-HTP affect the neurotransmitter serotonin(12); which plays an important role in our  overall well-being and happiness.

5-HTP is a precursor to serotonin, meaning once consumed, a chemical reaction occurs to naturally produce serotonin. So why not just take serotonin?

Serotonin is too large of a molecule to pass through the Blood-Brain Barrier. Precursors, however, are much smaller and therefore can pass though the Blood-Brain Barrier.

5-MT however is a precursor to melatonin. Why include a sleep aid in a fat burner? In addition to its role in sleep, melatonin has anti-inflammatory and antioxidant properties.

It’s also involved with regulating blood pressure, immune function, and body temperature. Serotonin also acts a precursor to melatonin, within the pineal gland, serotonin is acetylated and then methylated to yield melatonin(13).

So what does this mean?

The combination of 5-MT and 5-HTP may briefly(14) increase your serotonin levels and then yield to melatonin. However it is unlikely a user will experience the calming effects of melatonin due to the stimulant in lipodrene with ephedra.

lipodrene with ephedra whats left

Whats Left

If you’ve been following along in the label, you may have noticed we skipped a couple of ingredients. These include Cassia Nomame, Naringin , and 6,7 dihydroxybergamottin.

Cassia nomame may prevent the stomach and intestines from absorbing dietary fat. This causes dietary fat to be excreted, which might promote weight loss in some people(15).

Naringin helps burn fat by stimulating the production of a crucial fat burning hormone, adiponectin(16). When combined with synephrine, naringin may even increase energy expenditure(17). Like naringin,  6,7 dihydroxybergamottin also comes from grapefruit. Therefore may also help with weight control through similar mechanisms(18).

How to take Lipodrene?

Hi-Tech Pharmaceuticals recommends to take 1-2 tablets in the morning and 1 tablet after lunch. They also warn to not exceed 4 tablets daily.

lipodrene with ephedra who should try.

Who Should Try Lipodrene with Ephedra?

Lipodrene with ephedra may look intimidating from the amount of ingredients on the label; however, it’s actually a great fat burner for first time users and those with a higher tolerance to stimulants. With all supplements you should assess your tolerance, and with lipodrene that is very easy to do. With a max of 4 tablets daily, you can play around with the dose timing for what works best with you.

*Please note if your current health conditions are a concern, it is advised to speak to your own physician before taking supplements.

lipodrene with ephedra what to expect

What To Expect ?

Like most fat burners, lipodrene is stimulant dominant. So we expect the boost in energy and appetite suppression to be the most prominent effects of lipodrene. But as always user experiences vary.



lipodrene with ephedra stack

What’s similar ?

If you’re not sure if Lipodrene with ephedra is right for you, there are a ton of lipodrene versions you can checkout.

Like lipodrene but want more natural fat burning aid? Check out the Lipodrene Weight Loss Stack

Not enough energy from lipodrene? Check out Lipodrene Hardcore with Ephedra

Hardcore wasn’t hard enough? Check out Lipodrene Xtreme V2

Not sure if the lipodrene line is for ? Go over our Maximize your weight loss blog for a short comparison on our top selling fat burners of 2018.



Please Note

†The intention of the information above is for reference only. While we attempt to keep our information accurate, we cannot guarantee it is an accurate representation of the latest formulation of the product. If you have any concerns, please visit the vendors web site. The information above are the views of the product’s manufacturer, not the views of Same Day Supplements. The Food and Drug Administration has not evaluated these statements. The intention of this product is not to diagnose, treat, cure or prevent any disease or illness.

Does Lipodrene Work?
  • Energy without the Gitters Review by Dana : This is the 4th time I have purchased this product. It gives me the energy I need without the feeling that I had too much caffeine. Really helps the quality of my workouts. (Posted on 7/23/2018)
  • Perfect Pill Review by Traci : This little yellow pill will help you with hunger and give you a little boost in energy. I started taking these to help me prep for my bikini competition and continue to take them every now and then (Posted on 5/10/2018)
  • Works great when you use it right ! Review by Lakeba : I’ve taken these for awhile now..on & off for years ..the last few bottles I purchased from this site worked great!..curbed my appetite big time ..I only take 1 pill twice a day early morning then afternoon . when I’m doing a low carb diet this is my go to especially in the beginning when your getting into really helps !!. At one time I lost 30 lbs in 3 months in combination w/low carb diet . when I’m off low carb I still take them because it helps with junk food cravings. I do not Drink any caffeine beverage’s with it ..that’s a no no . i try & drink de cafe tea though its tough & i miss coffee at times ..this Lil pill alone will give you energy & can replace the coffee boost in the am at least for me it does. I’m not jittery but again I take 1pill not 2 at once .. If I take 2 together I get nauseated so test your tolerance & adjust .I dont take any pills after 2:30pm so my sleep isn’t disturbed ..but I go to bed late so others may need to adjust it to their night time routine. It definitely helps me get through those last few min of working out when I want to stop& rest lol & call it a day …hey for me it works ..but you need to combine it with healthy eating : moderate exercise.. Even walking will do . For me these fat burners , low carb diet ,moderate exercise, consistency &,patience always provides results .. (Posted on 5/2/2018)


Again because we all react to products differently, your individual results will vary. In order to better understand lipodrene’s effects lets look over some of the lipodrene reviews.