Synadrene By Hi-Tech Pharmaceuticals (Review)
📖 Table of Contents
When it comes to your weight-loss journey, choosing the right fat-burner can make all the difference—but with formulas changing under FDA scrutiny, it’s hard to know which product still delivers. That’s where Synadrene® by Hi-Tech Pharmaceuticals comes in. First released in 2016 using DMAA, it was reformulated in 2018 with the legal powerhouse DMHA to maintain its legendary energy, focus, and appetite-suppression effects. In this post, we’ll break down exactly what’s changed, who Synadrene is best for (and who should look elsewhere), and answer the most common questions—from dosing and side-effect tips to comparisons with other top stimulants on the market. Let’s dive in!
🔥 Synadrene – At a Glance
- Category: High-stim thermogenic / Cognitive-enhancing fat burner†
- Key Ingredients: DMHA, Caffeine, Sulbutiamine, Walnut Bark Extract, Yohimbine, Alpha Lipoic Acid, Green Tea, Poly-Thyronine†
- Best For: Experienced users seeking appetite suppression, clean energy, and mental focus†
- Notable Features:
- DMHA + caffeine combo for long-lasting energy†
- Includes nootropics for enhanced mood and clarity†
- Strong appetite suppression without the crash†
- Form: Capsule (proprietary blend, 815 mg per serving)
- When to Take: Morning or early afternoon (not within 6 hours of bedtime)
- Stackable With: CLA, L-Carnitine, stimulant-free thyroid or thermogenic formulas†
†Results may vary. Always follow label instructions and consult with a healthcare provider.
What is Synadrene?
Synadrene® is a high-stimulant fat burner developed by Hi-Tech Pharmaceuticals, formulated for individuals seeking serious energy, sharper focus, and stronger appetite control—especially during intense cutting phases. It first gained attention as a successor to Synedrex, a now-reformulated supplement that was once known for its intense thermogenic profile.†
Synadrene quickly became a go-to option for fans of DMAA-based products after the original OxyElite Pro and Hydroxycut Hardcore were discontinued or reformulated. Its claim to fame was mimicking the clean, euphoric, and appetite-suppressing effects of banned formulas, without technically using banned ingredients at launch.†
What makes Synadrene stand out is its balanced stimulant profile: you get sustained energy without excessive crash, thanks to a blend of DMHA, caffeine, Sulbutiamine, and green tea extract—plus adaptogenic herbs that support mood and metabolism. But don’t be fooled—it’s still one of the strongest fat burners on the market. It’s especially popular among users who:
- Have experience with high-stim supplements†
- Want help controlling cravings†
- Looking to break through fat-loss plateaus†
- Miss the effects of older DMAA-style formulas†
That said, Synadrene isn’t for everyone. If you’re new to thermogenics or sensitive to caffeine, you’ll want to start slow—or choose a lighter option altogether. But if you’re a seasoned user looking for a serious kickstart, Synadrene might be your next go-to.†
The Original Synadrene Ingredients:
When Synadrene first launched in 2016, it quickly made waves in the fat-burner community for one major reason—it contained DMAA (1,3-dimethylamylamine). The same powerful stimulant made OxyElite Pro and Jack3d infamous.†
DMAA was prized for delivering:
- Razor-sharp focus†
- Intense energy without a crash†
- Strong appetite suppression†
- Euphoric mood elevation†
But its strength was also its downfall. In 2013, the FDA began cracking down on DMAA-containing supplements, and by 2017–2018, manufacturers—including Hi-Tech Pharmaceuticals—were forced to remove it from all formulations.† Luckily, Synadrene wasn’t just about DMAA. It combined a synergistic blend of stimulants, antioxidants, nootropics, and metabolic enhancers, making it one of the most well-rounded fat-burners of its time.†
⚙️ Key Nutrients
- Vitamin B12, B6, and B3 (Niacin): These essential B vitamins support metabolic energy, helping your body convert food into usable fuel.†
- Chromium: Helps regulate blood sugar by supporting insulin’s ability to transport glucose into cells—an important factor in steady energy levels and appetite control.†
🔬 Original Proprietary Blend Highlights
- Methylxanthine (as Caffeine): A class of compounds that includes caffeine, theophylline, and theobromine. Most supplement labels use “methylxanthine” to refer to caffeine, a widely used stimulant that promotes alertness and thermogenesis. (1)
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Green Tea Extract: A powerful antioxidant that also acts as a natural thermogenic, supporting fat oxidation and increased calorie burn. (2)
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DMAA (1,3-Dimethylamylamine): The original heavy-hitter stimulant that provided euphoric energy and razor-sharp focus. (3)
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Sulbutiamine: A synthetic derivative of thiamine (Vitamin B1) that acts as a nootropic, supporting mood, cognitive clarity, and appetite suppression. (4)
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Sandalwood Extract: Believed to help reduce muscle cramping and support blood sugar regulation, although more research is needed. (5)
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Yohimbine Extract: A stimulant derived from yohimbe bark, often used to target stubborn fat and enhance blood flow. (6)
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Alpha Lipoic Acid (ALA): A potent antioxidant that may aid in weight management and improve insulin sensitivity. (7)
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Poly-Thyronine: A blend of thyroid hormone metabolites (e.g., T2) believed to support metabolism and appetite regulation—often added to fat burners for a subtle metabolic edge. (8)
Why Remove DMAA?
While DMAA was effective, the FDA ruled it was not a legal dietary ingredient, citing safety concerns over blood pressure and cardiovascular risk in August of 2018. This led to legal battles between Hi-Tech and the FDA, but ultimately, DMAA was banned in U.S. supplements. (9)
Hi-Tech pivoted, reformulating Synadrene to keep the product legal while still delivering similar benefits—enter DMHA.†
Though the original DMAA version is no longer available, it helped establish Synadrene’s reputation as one of the strongest fat-burners on the market. Many users still compare current formulas to that original blend, which is why understanding this history is key when evaluating how Synadrene performs today.†
If you’d like to read more about the change and DMHA, check out our DMHA Guide Blog!
Synadrene Now:
Today’s version of Synadrene® is still a high-stimulant thermogenic, but it’s been updated to meet modern supplement regulations, most notably by replacing DMAA with DMHA (2-Aminoisoheptane). While no longer containing banned stimulants, Synadrene remains one of the strongest legal fat-burners available, thanks to its potent blend of energy boosters, mood enhancers, and metabolic agents.†
🔁 What’s Changed?
The biggest shift is the removal of DMAA, which was banned by the FDA in 2017. To maintain Synadrene’s legendary punch, Hi-Tech Pharmaceuticals reformulated the product with DMHA, a similar stimulant that delivers:
- Strong mental focus and energy†
- Elevated mood and drive†
- Appetite suppression†
- Fewer side effects or crashes (for many users)†
Although DMHA is slightly milder than DMAA, most users describe its effects as smoother, longer-lasting, and still highly effective, especially when combined with caffeine and nootropic compounds like Sulbutiamine. (10)
Synadrene Ingredient Highlights
Here’s what you’ll find in the current formula:
- DMHA (2-Aminoisoheptane): A powerful DMAA alternative that supports clean, euphoric energy and intense focus.†
- Caffeine Anhydrous: A trusted stimulant that enhances alertness, performance, and thermogenesis.†
- Green Tea Extract: Rich in antioxidants and catechins like EGCG, supporting fat oxidation and metabolism.†
- Sulbutiamine: A synthetic vitamin B1 analog that boosts mood, cognitive clarity, and may help suppress appetite.†
- Walnut Bark Extract (Juglans Regia): A natural source of DMHA-like alkaloids, which may enhance the effects of synthetic DMHA.†
- Yohimbine HCl: Supports fat mobilization, especially in “stubborn” areas like the lower belly and thighs.†
- Alpha Lipoic Acid (ALA): Promotes antioxidant defense and may improve insulin sensitivity, helping the body utilize fat for fuel.†
- Poly-Thyronine: Contains thyroid hormone metabolites (T2) that may stimulate metabolism and calorie burn.†
🔸 Note: Synadrene contains a proprietary blend totaling 815 mg per capsule, so exact dosages of each ingredient are not disclosed.
⚖️ Is DMHA as Strong as DMAA?
Not quite—but it’s close.†
DMHA is often reported to be around 70–80% as strong as DMAA in terms of energy and euphoria, but many users appreciate its smoother onset, reduced crash, and longer duration. When paired with caffeine, green tea, and yohimbine—as it is in Synadrene—it becomes a serious stimulant combo with noticeable thermogenic effects.†
While the “old-school” DMAA version might have had a stronger impact on experienced users, the current DMHA formula remains a powerhouse—and importantly, it remains legal to sell in the U.S. as of now.†
Who Should (and Shouldn’t) Use Synadrene?
With a high-stimulant blend featuring DMHA, caffeine, yohimbine, and Sulbutiamine, this product is best suited for experienced users who want strong appetite suppression, clean energy, and serious motivation.†
✅ Synadrene Is Best For:
- Experienced stimulant users who have used products with DMAA, DMHA, or strong pre-workouts before†
- Individuals on cutting cycles who want to maintain energy and suppress appetite while in a calorie deficit†
- Busy professionals or early risers looking for all-day mental focus and drive†
- People who loved OxyElite Pro, Synedrex, or older Hydroxycut Hardcore formulas and want something similar in feel†
- Anyone hitting a weight-loss plateau and needing that extra metabolic push†
⚠️ Synadrene May Not Be Right For:
- First-time fat burner users: This formula is strong—if you’re new to thermogenics, consider starting with a milder product like HyperCuts or Raze†
- People sensitive to caffeine or stimulants: Side effects like jitters, rapid heartbeat, or trouble sleeping may occur at full dose†
- Anyone with pre-existing medical conditions, especially cardiovascular issues, high blood pressure, or thyroid disorders (always consult a doctor first)†
- Athletes subject to drug testing: DMHA may trigger false positives for amphetamines in certain tests†
Synadrene Benefits:
If you’re looking for a supplement that does more than just “give you energy,” Synadrene® delivers a multi-faceted thermogenic experience. It’s designed to help you tackle fat loss from several angles: energy, focus, appetite, and metabolism.
Here’s what you can expect when taking Synadrene:
⚡ 1. Clean, Long-Lasting Energy
Thanks to a blend of DMHA, caffeine anhydrous, and Walnut Bark Extract, Synadrene gives you a strong but smooth energy boost that kicks in within 30–45 minutes and lasts for hours.† Users often describe it as:
- “Clean focus without the crash”
- “All-day energy”
- “No need for coffee while on it.”
Unlike products that spike your energy then leave you drained, Synadrene is formulated to sustain performance throughout your day or workout.†
🔥 2. Thermogenesis and Fat Burning
Ingredients like green tea extract, yohimbine, and Poly-Thyronine work synergistically to boost your body’s core temperature and metabolic rate, helping you:
- Burn more calories at rest and during exercise†
- Break through stubborn fat-loss plateaus†
- Get leaner, faster†
This makes Synadrene especially effective when paired with a clean diet and regular training.†
🍽️ 3. Powerful Appetite Suppression
One of the standout features of Synadrene—especially noted in reviews—is how effectively it blunts cravings and reduces hunger.† This is where ingredients like:
- DMHA
- Sulbutiamine
- Caffeine
- Yohimbine
…all come together to help users stick to their diet without constantly thinking about food.†
🧠 4. Enhanced Focus and Mood
Fat burners often get a bad rap for making people jittery, but Synadrene adds in nootropics like Sulbutiamine to create a focused, motivated, and uplifted mental state.† Users frequently report:
- Better productivity†
- Sharper mental clarity†
- Elevated mood (without feeling “wired”)†
This makes Synadrene useful even on non-training days for productivity and appetite control.†
🛡️ 5. Antioxidant and Insulin Support
Lastly, ingredients like Alpha Lipoic Acid (ALA) and Chromium support healthy blood sugar and antioxidant defenses.† That means while Synadrene ramps up fat-burning, it also helps:
- Keep energy levels steady†
- Improve insulin function†
- Combat free radical damage†
Synadrene Reviews:
How To Take It:
To get the most out of Synadrene®, it’s important to use it correctly, especially because this is a high-stimulant formula. Following proper dosage and timing will help maximize fat loss while minimizing unwanted side effects like jitters or insomnia.
🕒 Suggested Use (From the Manufacturer):
- Start with one capsule in the morning
- If well-tolerated, take a second capsule 4–6 hours later
- Do not exceed 3 capsules per day
⚠️ Begin with the lowest effective dose to assess your tolerance, especially if you’re new to DMHA-based products.
🔁 Cycle Your Use
To avoid building a tolerance and to protect adrenal health:
- Use for no more than 8 consecutive weeks
- Take a 2–4 week break before starting a new cycle
💧 Stay Hydrated
Stimulants can act as mild diuretics and suppress appetite, so it’s easy to forget to drink water or eat enough. Be sure to:
- Drink plenty of water throughout the day
- Don’t skip meals—make sure you’re still fueling your body
Similar To Synadrene:
With so many fat burners on the market, how does Synadrene® stack up against popular alternatives like HydroxyElite, Lipodrene, and the legendary Synedrex? Below is a side-by-side look at how Synadrene compares in terms of stimulant content, intended use, and customer feedback.
Synadrene VS Hydroxyelite:
As we mentioned previously, HydroxyElite and Synadrene were both affected by the removal of DMAA, and as a result, both formulas now contain DMHA. Like Synadrene, HydroxyElite is often praised for its strong appetite-suppressing properties. So, which Hi-Tech fat burner is better?
If you’d like to read more about Hydroxyelite’s previous formula, read our Hydroxelite Review Blog. Or about how it compares to Oxyelite Pro, read Hydroxyelite VS Oxyelite Pro Blog.
🧪 HydroxyElite Current Formula Breakdown:
From the label, HydroxyElite contains:
- Bauhinia Extract
- Bacopa Extract
- Walnut Bark Extract
- Cirsium Oligophyllum Extract
- Rauwolscine Extract
- Garcinia Cambogia Extract
- DMHA
- Caffeine
🔍 How Does It Compare to Synadrene?
When compared to Synadrene, three ingredients are directly shared:
- Caffeine
- DMHA
- Walnut Bark Extract
There is also a similar fourth ingredient pair: Yohimbe (Synadrene) and Rauwolscine (HydroxyElite).
Rauwolscine is a metabolite of Yohimbine and works mainly by blocking alpha-2 adrenergic receptors located in fat cells. When Rauwolscine binds to a fat cell, it “turns off” the alpha receptor, allowing fat to be mobilized and burned off more effectively. (12)
The other ingredients in HydroxyElite focus on:
- Thermogenesis: Cirsium Oligophyllum†
- Appetite Suppression: Garcinia Cambogia†
- Mood/Focus: Bacopa Extract†
- Metabolism Support: Bauhinia Extract†
Is Hydroxyelite Better?
After comparing the labels and user reviews, we would say:
- HydroxyElite may be better for individuals seeking a strong appetite suppressant with additional mood support (thanks to Bacopa Extract and Garcinia Cambogia).†
- Synadrene, on the other hand, may better suit individuals looking for sustained energy, mental focus, and thermogenesis throughout the day.†
- While both contain DMHA and caffeine, Synadrene’s inclusion of Sulbutiamine may offer more cognitive clarity and motivation, especially during calorie-restricted periods.†
If you’re looking for an alternative to these fat burners or a better appetite suppressant, we recommend checking out Methyldrene Elite. For information on how Hydroxyelite and Methyldrene Elite compare, check out our blog!
Synadrene VS Lipodrene With Ephedra
When it comes to high-stimulant fat burners, Synadrene and Lipodrene with Ephedra are two of the most popular formulas from Hi-Tech Pharmaceuticals. While they share similar goals—boosting energy, burning fat, and suppressing appetite—their ingredient profiles and user experiences differ in key ways.†
Let’s break it down.
🧪 Lipodrene Current Formula Breakdown:
From the label, Lipodrene with Ephedra contains:
- Ephedra Extract (25 mg)
- Caffeine Anhydrous
- Senegalia Berlandieri Extract
- Theobromine
- Synephrine HCl (from Citrus Aurantium)
- Green Tea Extract
- Hoodia Extract
- 5-HTP
- Yohimbine HCl
- Naringin, Huperzine A, and other metabolism and focus-support ingredients
Lipodrene is often praised for its fast-acting, intense thermogenesis and appetite suppression, especially for stubborn fat areas. It uses a blend of ephedra alkaloid-free extract, caffeine, and synephrine to create a powerful stimulant effect.†
🔍 How Does It Compare to Synadrene?
Synadrene and Lipodrene both include DMHA, caffeine, green tea, and yohimbine, but they diverge in intensity and application:
- Lipodrene uses Ephedra Extract, which many users describe as delivering a faster, more aggressive energy spike, especially in combination with Synephrine and Senegalia Berlandieri.†
- Synadrene relies on Sulbutiamine and Walnut Bark Extract for smoother energy, enhanced focus, and mood support—ideal for users who want a cleaner experience without the crash.†
- Lipodrene’s formula includes multiple mood-boosting and appetite-suppressing botanicals, making it feel more stacked, while Synadrene is more focused on mental clarity and sustained stimulation.†
Is Lipodrene Better?
That depends on your goals:
- Lipodrene may be better for users who want immediate, high-impact energy with a hard-hitting thermogenic effect and a robust blend of fat-burning ingredients. The addition of Ephedra Extract makes it feel more like the “old-school” fat burners of the early 2000s.†
- Synadrene may be better suited for individuals seeking clean, long-lasting energy, strong appetite control, and sharper mental focus throughout the day.†
If you’ve had success with ephedra-based supplements in the past or want something that hits hard and fast, Lipodrene might be your best bet. If you prefer something smoother, more nootropic-focused, and less likely to cause a crash, Synadrene is the way to go.†
Synadrene VS Synedrex
Synadrene® and Synedrex® (by Metabolic Nutrition) are both high-stimulant thermogenic fat burners built around DMHA-era formulas—but they take very different approaches to energy, appetite control, and fat loss. Synedrex is positioned as a next-generation neurothermogenic, delivering both metabolic intensity and nootropic sharpness with a sophisticated mix of ingredients.†
🧪 Synedrex – Ingredient Highlights:
Synedrex is designed to deliver a multi-layered fat-burning experience, combining powerful stimulants, mood boosters, thermogenics, and nootropics:
- Caffeine Anhydrous: Boosts energy, alertness, and thermogenesis.†
- Eria Jarensis Extract: Often paired with or used as an alternative to DMHA; delivers euphoric energy and strong mood elevation.†
- Naringin (98%): Enhances thermogenesis and may improve the absorption of other ingredients.†
- Grains of Paradise & Evodiamine: Heat-producing compounds that help increase core temperature and calorie expenditure.†
- Yohimbine HCl + Alpha Yohimbe (Rauwolscine): Dual-action fat mobilizers targeting stubborn fat through alpha-receptor blocking.†
- Vanadyl Sulfate + Chromium Polynicotinate: May support insulin sensitivity and healthy blood sugar metabolism.†
- L-Dopa (99%): Precursor to dopamine, may improve mood, focus, and motivation.†
- Huperzine A: A cognitive enhancer that supports memory, mental sharpness, and neurotransmitter function.†
- Black Pepper Extract (Piperine): Improves bioavailability of the entire formula.†
- Poly-Thyronine Extract: Aids metabolic activity via thyroid hormone metabolites.†
🔍 How Does It Compare to Synadrene?
While both products fall under the hardcore thermogenic category, their ingredient profiles and effects differ:
- Synadrene delivers clean, long-lasting energy, a strong appetite-suppressant effect, and mood elevation through Sulbutiamine and DMHA.†
- Synedrex focuses on neuro-stimulation, using Eria Jarensis, Huperzine A, and L-Dopa to enhance cognition, mood, and motivation alongside fat loss.†
- Synedrex also includes Grains of Paradise and Evodiamine, ingredients known for increasing core body temperature and promoting non-stimulant thermogenesis.†
While both include caffeine, yohimbine, and poly-thyronine, Synedrex adds more dopaminergic and neurological compounds, whereas Synadrene leans heavier into suppressing hunger and delivering all-day productivity.†
Is Synedrex Better?
It depends on what you’re looking for:
- Synedrex may be better if you want a nootropic-heavy fat burner with feel-good energy, mental focus, and intense thermogenesis via ingredients like Eria Jarensis, L-Dopa, and Huperzine A.†
- Synadrene may be the better fit if your priority is controlling appetite, staying locked in all day, and avoiding stimulant “crashes.” It’s also a great option if you prefer the smoother stimulation of DMHA over Eria Jarensis.†
Read more about Synedrex: Synedrex Review Blog!
Where To Buy Synadrene?
Ready to take the next step in your fat loss journey? You can get Synadrene® by Hi-Tech Pharmaceuticals right here at SameDaySupplements.com!
- 🚚 In stock and ships fast (Mon–Fri before 3 PM EST)
- ✅ Authentic products from Hi-Tech Pharmaceuticals
- ⭐ Verified customer reviews to help guide your purchase
- 💥 Bundle deals available with CLA, Carnitine, and more
Whether you’re chasing smooth, all-day energy and serious appetite suppression or just need a reliable fat burner to break through your plateau, Synadrene has you covered, with proven performance and Same Day service.†
Wrapping Up!
This concludes our comparison of Synadrene. Thank you for reading. If you have any questions, need a recommendation, or have a topic you’d like us to cover in a future blog, please send us an email!
Meanwhile, if you are looking for more to read, check out some of our other blogs!
-
- Skald Fat Burner Review 2024: Does it Live Up to the Hype?
- Top 8 Supplements for Relieving Muscle Cramps
- Hydroxytyrosol: Guide To How Olive Oil Antioxidants Can Benefit You Today
- Is GABA the Missing Piece to Your Well-being? (Understanding What It Is And Why It Matters Today)
- Supercharge Your Health Today with Methylcobalamin: A Look at Sublingual B12
- Do Hair Loss Supplements Really Work? Exploring the Benefits of Nutrafol®
For more information on the previous version of Synadrene, check out Trainer Joe B’s Video!
Side Effects And Warnings:
Not for use by individuals under the age of 18 years. Do not use it if you are pregnant or nursing. This product can raise blood pressure and interfere with other drugs you may be taking. Talk to your doctor about this product. Individuals who consume caffeine with this product may experience serious adverse health effects. Individuals who are sensitive to the effects of caffeine should consult a licensed healthcare professional before consuming this product.
Do not consume synephrine or caffeine from other sources, including but not limited to coffee, tea, soda, or other dietary products or medications containing caffeine or phenylephrine. Do not use it for more than 8 weeks.
Consult with your physician prior to use if you are taking medication, including but not limited to MAOI inhibitors, Aspirin, antidepressants, nonsteroidal anti-inflammatory drugs, or products containing phenylephrine, ephedrine, pseudoephedrine, or other stimulants.
Consult your physician prior to use if you have a medical condition, including but not limited to heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate, or glaucoma.
Discontinue 2 weeks prior to surgery or if you experience rapid heartbeat, dizziness, severe headache, or shortness of breath. In case of accidental overdose, seek professional assistance or contact a poison control center immediately.
Avoid alcohol while taking this product. Exceeding the recommended serving may cause serious adverse health effects, including a heart attack and stroke. Improper use of this product may be hazardous to a person’s health.
This product may contain ingredients that are banned by some sports organizations and/or increase the risk of false positives on a drug test. Please consult with your sports organization or physician before taking this product.
Disclaimer:
†Please note the intention of the information provided is for reference only. Furthermore, we are in no way providing medical advice or instruction. Instead, the information provided in this guide/blog utilizes anecdotal information and available studies/reviews. While we aim to maintain and display accurate information, we can’t guarantee it represents the latest product formula or information. Therefore, please visit the manufacturer’s website if you have any concerns. Also, the information above does not represent our views here at Same Day Supplements. Instead, these are the manufacturers’ and users’ views and information. Additionally, the Food and Drug Administration has not evaluated these statements. Finally, these products aim not to diagnose, treat, cure, or prevent disease or illness.
