How Laxogenin Can Improve Muscle Growth
📖 Table of Contents
When it comes to building muscle and recovering faster, most lifters want results without the risks that come with prohormones or SARMs. That’s where Laxogenin comes in. Marketed as a natural plant‑derived anabolic, Laxogenin has been gaining attention for its potential to support lean muscle growth, enhance recovery, and improve performance, without altering your hormone levels.†
But does it really work? And how does it compare to other natural anabolics or muscle‑building supplements on the market? In this guide, we’ll break down everything you need to know about Laxogenin—from what it is, to its benefits, side effects, and how to stack it for the best results—so you can decide if it’s the right addition to your routine.
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If you’re curious about anything related to Laxogenin that we don’t cover here, feel free to contact us directly. We’re here to help you navigate the latest information and make informed decisions about your fitness journey. Just contact us, and we’ll get in touch ASAP!
🔥 Laxogenin – At a Glance
- Category: Natural anabolic / muscle-building supplement†
- Key Ingredient: 5α-hydroxy-laxogenin (plant-based sapogenin)†
- Best For: Athletes and lifters looking for muscle support without hormones or prohormones†
- Notable Features:
- May promote protein synthesis and recovery†
- Marketed as “non-hormonal anabolic support”†
- Often stacked with prohormones or standalone muscle builders†
- Form: Capsule (common doses range 25–100mg per serving)
- When to Take: Daily, often split AM/PM depending on formula
- Stackable With: Ecdysterone, Turkesterone, prohormones, or natural test boosters†
†Results may vary. Scientific evidence is limited, and more human research is needed. Always follow label instructions and consult with a healthcare provider.
What Is Laxogenin?
Laxogenin, also known as 5α‑Hydroxy Laxogenin or Laxo‑100, is a naturally occurring plant steroid. It belongs to a unique group of compounds called brassinosteroids—plant hormones that regulate growth and development. Laxogenin can be extracted from several botanical sources, but the most common is Smilax sieboldii, a plant closely related to asparagus. (1,2,3,4,5)
Other reported sources include:
- Allium chinense (a type of Chinese onion)
- Diosgenin (found in wild yam and fenugreek)
Plant Hormones vs. Human Hormones
Just as testosterone and estrogen influence processes in the human body, brassinosteroids are essential for plant vitality. They regulate:
- Cell division & elongation†
- Protein synthesis†
- Overall plant growth and resilience†
Chemically, brassinosteroids share structural similarities with cholesterol, a molecule also used in the human body as a building block for steroid hormones like testosterone. This similarity is one reason why scientists and supplement formulators have explored their potential anabolic effects in humans.†
The Anabolic Connection
Both plant sterols and testosterone stem from a common backbone molecule, 5α‑cholestane. While their functions diverge—brassinosteroids focusing on plant health and human steroids regulating metabolism, immune response, and sexual development—recent research has suggested that brassinosteroids may carry anabolic‑like properties in humans. This means they could:
- Promote muscle growth and protein synthesis†
- Support strength and recovery†
- Do so without the androgenic side effects linked to anabolic steroids and many prohormones†
This distinction makes Laxogenin supplements appealing to athletes, lifters, and fitness enthusiasts who want performance enhancement without committing to hormonal compounds or requiring post‑cycle therapy (PCT).†
⚠️ Important Note: While Laxogenin itself is non‑hormonal, some formulas on the market combine it with DHEA‑based prohormones or other anabolic agents. Always review ingredient panels carefully before purchasing.†
How Does Laxogenin Work?
While research on Laxogenin is still emerging, studies on this compound and other brassinosteroids (the plant family it comes from) give us clues about how it may support muscle growth and performance.† Here’s what the science suggests:
1. Mimicking Hormone Activity
Research shows that 5α‑hydroxy‑laxogenin can interact with androgen receptors—the same receptors testosterone binds to. At higher concentrations, it appears to “switch on” these receptors, which may help signal the body to build more muscle. (5)
2. Supporting Protein Synthesis
Muscle growth depends on two things: building new proteins and preventing muscle breakdown. In cultured rat muscle cells, brassinosteroids (the family of plant steroids that includes Laxogenin) have been shown to increase protein synthesis while simultaneously suppressing protein breakdown. This dual activity helps create an “anabolic state” ideal for muscle gain. Studies suggest this effect operates through key growth-signaling pathways like AKT/PKB, well-known in muscle-building research. (1,7)
3. Helping Muscle Fibers Grow & Mature
Experiments on muscle cells in the lab found that brassinosteroids can increase myotube formation, helping immature muscle fibers fuse together and mature. This suggests Laxogenin may not only make existing muscle stronger but also help form new muscle fibers, improving quality and structure, not just size. (7)
4. Blocking the “Muscle Growth Brake” (Myostatin)
Newer computer and lab studies suggest that Laxogenin may also work by interacting with myostatin, a natural protein in the body that limits muscle growth. (7)
- In simulations, Laxogenin showed strong binding to myostatin.†
- In muscle cell experiments, even very small amounts helped lower myostatin levels and encouraged muscle fiber development.†
- Researchers also noticed antioxidant activity, which could reduce stress on muscle cells and support faster recovery.†
The takeaway: Laxogenin seems to create a more “muscle‑friendly” environment by activating growth signals, supporting protein synthesis, promoting new muscle fibers, and possibly blocking myostatin’s muscle‑limiting effects. While most of this research comes from lab studies—not yet large human trials—it helps explain why many athletes and lifters are interested in it as a natural, non‑hormonal anabolic option.†
Benefits Of Laxogenin:
Based on early research and user reports, here are the most talked‑about benefits of Laxogenin:
- Lean Muscle Growth & Preservation: Laxogenin may help boost protein synthesis—the process your body uses to build new muscle tissue—while limiting muscle protein breakdown. Together, these effects support lean muscle growth and can help preserve size and strength during calorie restriction or intense training cycles. (1,2,5,7)
- Adaptogenic Stress Support: Some research suggests Laxogenin may have adaptogenic properties, helping the body better handle stress and improve overall resilience, both inside and outside the gym. (5)
- Faster Recovery Between Workouts: Many athletes report reduced soreness and quicker recovery times, allowing for more frequent training and steady performance improvements.†
- Metabolic & Body Composition Support: While not a direct fat burner, users often find it easier to maintain a leaner physique when supplementing with Laxogenin. There’s also early evidence that it may support thyroid function and contribute to healthier metabolism and energy levels. (8)
- Potential Cardiovascular Benefits: Preliminary studies suggest modest improvements in cholesterol levels, including a reduction in LDL (“bad”) cholesterol, which could provide additional support for heart health. (9)
- Joint Health & Injury Recovery: Beyond muscle, Laxogenin has a strong reputation for supporting joint comfort and recovery. Users frequently note less shoulder, knee, or back pain, with some even reporting faster healing from injuries or surgeries. This may be linked to its anti‑inflammatory and cortisol‑balancing properties, making it especially appealing to older lifters or anyone managing chronic aches. (10)
Bottom line: Laxogenin stands out because it’s non‑hormonal—meaning no PCT is required—and offers a wide range of possible benefits for muscle, recovery, joints, and overall well‑being. That said, responses can vary: some users experience multiple benefits, while others notice subtler effects.
Laxogenin FAQs:
In this section, we address some common questions about Laxogenin.
How Should I Take Laxogenin? |
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Follow the directions on your chosen brand’s label. Most products recommend taking 1–2 capsules daily (typically 50–200 mg total) with food for best absorption and to reduce stomach upset.† |
Do I Need To Cycle Laxogenin? |
Yes, cycling is recommended even though it’s non‑hormonal. Typical cycles last 8–12 weeks, followed by a 4‑week break. Unlike prohormones or anabolic steroids, you do not need a PCT (post‑cycle therapy).† |
Is It Safe? |
Laxogenin is generally considered safe for healthy adults. Reported side effects are rare, though some users note mild headaches or digestive discomfort at higher doses (200mg+). As always, consult a healthcare provider before use.† |
Can Women Take It? |
Yes. Because it does not affect hormones, Laxogenin is popular among women seeking to enhance muscle tone, recovery, or fat loss. It’s considered suitable for both men and women.† |
Will I Need To Take A PCT After My Cycle? |
No. Since Laxogenin is non‑hormonal, there’s no suppression of testosterone or estrogen, and therefore no need for post‑cycle therapy.† |
Can Laxogenin Be Stacked With Other Supplements? |
Yes. It is often stacked with creatine, BCAAs, or natural muscle‑building products. Many brands also combine Laxogenin with compounds like epicatechin or turkesterone for synergistic effects.† |
Does It Help With Joint Pain? |
Many users highlight joint relief as one of the biggest benefits. Laxogenin’s anti‑inflammatory properties may ease pain in knees, shoulders, and elbows, while supporting faster recovery from injuries.† |
Will I Lose My Gains After I Stop Taking Laxogenin? |
No, not typically. Because Laxogenin is non-hormonal, it doesn’t cause the same rebound or muscle loss risks seen with anabolic steroids or prohormones. As long as you maintain proper training, diet, and recovery, most users can keep their strength and muscle gains after cycling off.† |
Similar To Laxogenin:
Now, let’s get into the good stuff! Before committing to laxogenin, we must see how it compares to other compounds and products.
Pro Hormones VS Laxogenin: 
Prohormones and Laxogenin are often confused, but they’re very different. Prohormones directly affect your hormones by converting into anabolic steroids in the body. This usually leads to more dramatic results in strength and size, but also carries greater risks, including side effects like estrogenic rebound, liver strain, and the need for post-cycle therapy (PCT).†
You can read more about prohormones in our guide. This guide covers common prohormones, their effects, side effects, and PCTs.†
Laxogenin, on the other hand, is completely non-hormonal. It doesn’t require PCT and is considered safe for both men and women. However, because of this, its effects are more subtle compared to prohormones. Where it shines is joint health—some prohormones can “dry out” joints, but Laxogenin may help cushion that with anti-inflammatory support. For this reason, it’s often stacked with prohormones to help offset side effects.† And if you’re taking a prohormone that doesn’t feature laxogenin in the formula, you can stack them.†
Prohormones With Laxogenin: |
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Epicatechins VS Laxogenin: (11,12)
Epicatechin is a flavonoid found naturally in dark chocolate and tea leaves. Like Laxogenin, it’s non-hormonal and safe for men and women. What makes epicatechin exciting is its ability to boost nitric oxide (N.O.) levels, which improves blood flow, endurance, and that “pump” sensation during workouts.†
But beyond pumps, epicatechin has gained attention for its potential to inhibit myostatin, a protein that limits muscle growth. By suppressing myostatin and upregulating follistatin, epicatechin may unlock greater potential for lean mass development, making it a perfect partner to stack with Laxogenin, which promotes protein synthesis and recovery.†
If you’re looking for a more natural muscle-building stack, you can try the Women’s Muscle Building stack from Blackstone Labs (it’s not just for women). Or you can try stacking a laxogenin with a myostatin inhibitor like Epicat, Myostato, or Myo-stack.†
Epicatechins With Laxogenin: |
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Adaptogens VS Laxogenin: (13)
Adaptogens are plant-based compounds that help the body adapt to stress, often by lowering cortisol (the “stress hormone”). High cortisol can interfere with recovery, muscle growth, and even fat loss. Common adaptogens include Ashwagandha (stress relief), Rhodiola (endurance), and Cordyceps (stamina).†
Cortisol has its purpose in the body, but when cortisol levels are too high, you can expect:
- High blood pressure†
- A flushed face†
- Muscle weakness†
- Increased thirst†
- Urinating more frequently†
- Changes in mood, such as feeling irritable or low†
- Rapid weight gain†
- Osteoporosis†
While Laxogenin shows some adaptogenic-like effects—particularly in supporting cortisol balance—it isn’t formally classified as one. Pairing Laxogenin with a true adaptogen may provide a more complete recovery stack, helping with muscle growth while reducing stress-related setbacks.†
Adaptogens With Laxogenin: |
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Turkesterone / Ecdysterone VS Laxogenin: (14,15)
Turkesterone and its close cousin, Ecdysterone (Beta-Ecdysterone), are part of a class called ecdysteroids, which are naturally occurring plant and insect hormones. Like Laxogenin, they’re considered non-hormonal muscle builders and are popular among lifters looking for a safer alternative to prohormones. Neither requires PCT, and both are suitable for men and women.†
Laxogenin belongs to the brassinosteroid family, while Turkesterone/Ecdysterone are ecdysteroids. Both support protein synthesis but through different pathways, which is why some users like to stack them for complementary benefits.† Human data on Laxogenin is limited, but animal and cell studies suggest it may support recovery and muscle growth. Turkesterone and Ecdysterone, on the other hand, have been studied more directly for muscle hypertrophy. A notable study on Ecdysterone reported increases in lean muscle mass and strength in trained individuals, lending credibility to the idea that these plant compounds can impact performance.†
Popular Products:
Here at Same Day Supplements, we currently carry three Laxogenin products as standalone items. But there are a bunch of products and stacks that feature it in the formula.
Laxogenin 100 By Hi-Tech Pharmaceuticals:
How To Take Hi-Tech Pharmaceuticals Laxogenin 100:
The manufacturers recommend taking two (2) tabs daily.
Laxogenin 100 Review By Carter: “Love Laxogenin. Best natty product I’ve ever used and I take it 6 months out of the year! I always feel very positive on it and it does help put on a modest amount of size. Where it really shines I notice is my muscles get a lot harder on it and strength goes up pretty dramatically. This is the best brand for this product and it’s a great supplement. Highly recommend.”
Anogenin By Blackstone Labs:
How To Take Blackstone Lab’s Anogenin:
The manufacturers recommend taking one (1) to two (2) capsules per day with food. They also suggest using in cycles of 8-12 weeks with at least 4 weeks off in between cycles.
Anogenin Review By Rosa: “More lean and strength gone up. Looking better everyday.”
Laxogenin+ By REPP Sports:
How To Take REPP Sports Laxogenin+:
The manufacturers recommend two (2) capsules daily with 8oz of water for men, but suggest women take one (1) capsule daily with 8oz of water.
Laxogenin+ Review By Rory: “Only been using for two weeks, but I can already see growth, and seems to add a bit of endurance, also better recovery.”
Laxogenin Stacks:
In addition to standalone use, stacking Laxogenin with other supplements can amplify its benefits for muscle growth and overall performance. Here are some effective stack options:
- Hi-Tech Prohormone + Laxogenin Stack – 4 Week Cycle:
This cutting-stack combination combines your choice of Hi-Tech Pharmaceuticals prohormones and Laxogenin, creating a synergy that maximizes muscle growth, strength gains, and performance enhancement.† Your chosen prohormone can assist in promoting rapid muscle development and enhancing athletic performance, complemented by the muscle-supporting properties of Laxogenin.†
- Lipodrene Before and After Boost Kit:
This unique kit includes two of Hi-Tech Pharmaceuticals’ most talked-about products: Lipodrene with Ephedra – 90 Tablets and Laxogenin 100 – 60 Tablets. Together, these supplements offer a supportive approach to your weight loss or muscle-building goals, providing a comprehensive solution for enhancing your physique and performance.†
- Power of 3 Stack:
Elevate your muscle-building potential and recovery with the Power of 3 Stack from Hi-Tech Pharmaceuticals.† This ultimate trio combines the anabolic strength of Laxogenin, the potent muscle support of Turkesterone 650, and the recovery-enhancing power of HMB to provide a comprehensive solution for advanced athletes and bodybuilders.†
- The Natty Stack:
Combining Hi-Tech Pharmaceuticals Laxogenin 100, Turkesterone 650, and Hi-Tech Fish Oil, the Natty Stack offers a balanced approach to muscle growth and overall health. Fish oil provides omega-3 fatty acids crucial for muscle function and cardiovascular health, enhancing the benefits of Laxogenin and Turkesterone in promoting recovery, joint health, and muscle growth.†
- Other Stacking Options:
For muscle-building, consider stacking Laxogenin with Halo Elite from Blackstone Labs. Halo Elite features a plant-derived androgen that enhances protein synthesis without affecting testosterone levels. Pairing Halo Elite with Laxogenin can create a potent muscle-building stack, with the addition of epicatechin for enhanced fat loss benefits. Laxogenin can be stacked with your favorite fat burner for fat loss goals. If you prefer a stimulant-free option, consider stacking it with supplements like Recomp-RX, CLA, L-Carnitine, or another stimulant-free blend to support your body composition goals effectively.†
Where To Buy Laxogenin?
Ready to try Laxogenin for yourself? You can get it right here at SameDaySupplements.com!
🚚 In stock and ships fast (Mon–Fri before 3 PM EST)
✅ Authentic products from top supplement brands
💥 Bundle deals available with natural anabolics & recovery agents
Whether you’re stacking with prohormones, chasing lean muscle gains, or testing a natural anabolic edge, Laxogenin has you covered, with proven Same Day service.†
Wrapping It Up!
And this marks the end of our post on Laxogenin. Thank you for reading! And as always, if there’s something unclear, you have another question, or you have another idea for a blog, email us!
Are you looking for more to read? Check out some of our other blogs!
- The Ripper Fat Burner Review And Comparisons
- Does Wrecked Pre Workout Match The Hype? (Review And Comparisons)
- Natural Testosterone Boosters Guide
- Prohormone Guide Blog
- The Best Tongkat Ali Supplements For You
- How To Build Muscle With Turkesterone
- Post Cycle Therapy Blog
Warnings And Side Effects:
Keep out of reach of children. Do not use products in this post if you are at risk for or are being treated for high blood pressure, heart, kidney, thyroid, or psychiatric disease, anxiety, depression, seizure disorders, strokes, or other medical conditions.
Do not take the products in this post if you are using anti-depressants, MAO/MAOI inhibitors, or any other prescription drugs. Not for use by anyone under 18. Women who are pregnant or nursing should not use this product.
This product may elevate serum hormone levels, which could produce positive results if you are subject to NCAA testing, for use by healthy individuals only. Do not use it if the seal is damaged or missing. Store in a cool, dry place.
Disclaimer:
†PLEASE NOTE: The information provided on this page is intended for general reference only. While we strive to ensure accuracy and currency, we cannot guarantee that it reflects the latest product formulation or specifications. For the most up-to-date details, please consult the manufacturer’s official website. The content here is drawn from manufacturer-provided materials and user reports and does not constitute our own endorsements. The Food and Drug Administration has not evaluated these statements. This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition.