How Laxogenin Can Improve Muscle Growth

How Laxogenin Can Improve Muscle Growth

Laxogenin, aka 5a-Hydroxy, has been around for a while. We’ve already covered some of the basics back in 2016. In this post, we’re going to go as deep as the recent research allows us.

We’re going to cover :

If you have a question that we don’t answer, contact us HERE and we’ll get back to you ASAP!THE BASICS

The Basics(1,2,3,4,5,6)

So what is 5a-Hydroxy Laxogenin?

The more understood definition of laxo is that it’s a plant steroid. But, more specifically it belongs to a class of plant hormones called brassinosteroids. It can be extracted from several plants, but the most common is Smilax sieboldii. This plant is very similar to asparagus.

Some of the other plant sources include:

  • Allium chinense
  • Diosgenin

Steroids in plants play a similar role as hormones in humans; they promote growth.

plant-hormone-vs-mammal-hormone laxo

To understand the similarities between plant sterols and human steroids, we have to look into their structures.

Brassinosteroids are plant-specific polyhydroxylated derivatives of 5α-cholestane.
This is structurally similar to cholesterol-derived animal steroids.

Cholesterol is one of the building blocks of testosterone. Where 5α-cholestane is a metabolite of Cholesterol.

Brassinosteroids specifically is essential for the growth and development of plants. In humans, though, studies indicate that some brassinosteroids exhibited anabolic effects. But that’s not all. It also indicated that these effects were experienced without the side effects common to steroids/prohormones.

This is why you can cycle a product containing brassinosteroids and not worry about a PCT. However, it is important to check all compounds in the formula, as they may feature a DHEA based prohormone.

What are the benefits of Laxogenin?

While everyone’s experience will be different, there are some effects (noted by customers and some studies) that have helped build laxogenin’s reputation:

  • Aiding In Muscle Recovery
  • Promoting An Increase In Protein Synthesis
  • May Have Adaptogenic Properties
  • May Relieve Inflammation And Pain
  • Assists In Fat Loss
  • Helps Reduces LDL “Bad” Cholesterol
  • May Improve Thyroid Function
  • May Limit Protein Breakdown

That’s a pretty large list for one ingredient, especially a non-hormonal one. Unfortunately, we can’t say any effect will be experienced. Some customers get them all and more, while others don’t feel anything.


The FAQs Laxogenin

In this section, we’re going over some of the more common questions on Laxogenin. But, if you have a question that’s not answered below, send us an email.

“How should I take Laxogenin?”

Each brand of Laxogenin will have their recommendations on how to take their product. Generally, it is preferred to take with food.

“Do I need to cycle Laxogenin?”

Yes. Although this product is non-hormonal it is still recommended to cycle it. However, during your off period, you will not need a PCT. You can use it in cycles of 8-12 weeks, taking at least 4 weeks off between cycle. 

“Is it safe?”

Yes! The only side effect currently noted from laxogenin is a headache. But, this was after consuming a higher dosage (i.e., over 200mg).

“Can women take it?”

Absolutely! Many women chose to supplement with Laxo to help build muscle and burn fat. Laxogenin is great for men and women as it won’t affect your hormone levels, but can enhance your performance and physique.



Now let’s get into the good stuff! Before we can commit to laxogenin, we have to see how it holds up against other compounds and products. 

Pro Hormones 1-AD

These are two different things that are often confused. First things first, a prohormone will affect your hormones. Because of this, the effects are generally more powerful. But, you also carry greater risk for side effects. Also, prohormones have to be cycled and be followed by a PCT.

You can read more about prohormones in our guide (which is linked). In this guide, we go over common prohormones, their effects, side effects, PCTs and more.

As we mentioned before, laxogenin will not affect your hormones. This is why it’s safe for men and women to take. While these prohormones and laxogenin are different compounds, it’s is common to see laxogenin featured in a prohormone formula. 

Because of the prohormones, you won’t notice the strength gains from the laxogenin alone. But, for compounds that are more likely to “dry out” your joints, laxogenin can be a great addition to aid in join support. And if you’re taking a prohormone that doesn’t feature laxogenin in the formula, you can stack them.

Epicatechins  (7,8)RHODIOLA

Epicatechins are another plant-derived compound. More specifically, epicatechin is a flavonoid found in dark chocolate, which is harvested from the cacao tree. So once again, non-hormonal and safe for both men and women to take.

Why do we love epicatechin? For starters, it can increase nitric oxide in the body. When you’re in the gym and you have a really good pump and maybe some vascularity gains, you have your N.O. to thank.

But, outside of aesthetics, this increase in N.O. means there’s an increase in blood flow (vasodilation). The opposite of a vasodilator is a vasoconstrictor; stimulants fall into this category. 

Why do we want vasodilation over vasoconstriction? An increase in blood flow means an increase in oxygen and nutrients. This ultimately means; improved endurance, power, recovery, and growth.

That alone is a great property. But, it’s not the one epicatechin is famed for. Epicatechin may also inhibit Myostatin and therefore up-regulate Follistatin. 

These are Myokine’s produced from your muscle cells. They work together in a ratio, Myostatin inhibits/suppresses muscle growth, while Follistatin increases it. So, by inhibiting Myostatin, you’re increasing your potential muscle growth.

Laxogenin may boost nitrogen retention, but this effect isn’t something it’s known for. Instead, these compounds work very well together so they work much better in a stack. If you’re looking for a more natural muscle building stack, you can try the Women’s Muscle Building stack from Blackstone labs (it’s not just for women). Or you can try stacking a laxogenin with a myostatin inhibitor like Epicat, Myostato, or Myo-stack.RHODIOLA

Adaptogens  (9)

Adaptogens are plants that promote the resistance stressors, whether physical, chemical, or biological. In a way, this means it can be hormonal. But, not like a prohormone. An adaptogen can help reduce cortisol, the hormone released by the body when we’re stressed. Cortisol has its purpose in the body, but when cortisol levels are too high you can expect:

  • high blood pressure.
  • a flushed face.
  • muscle weakness.
  • increased thirst.
  • urinating more frequently.
  • changes in mood, such as feeling irritable or low.
  • rapid weight gain
  • osteoporosis.

And more. Now, an adaptogen isn’t going to be a miracle pill for anxiety and stress. It may help, but it won’t take the place of medication or therapy. Also, something to consider, different plants are going to have a different effect. So one that boosts stamina (Cordyceps) and one that reduces stress and anxiety (Ashwagandha), are both still adaptogens.

Laxogenin has adaptogenic properties; it can help reduce cortisol but we wouldn’t classify it as an adaptogen. So if you’re looking to build muscle and want to reduce cortisol, laxogenin is a great product for you. But, it probably won’t be as noticeable as if you took an adaptogen with that purpose.


Where Can You Buy It

Here at Same Day Supplements! We currently carry 4 products with just Laxogenin. But there are a bunch of pro-hormones that feature it in the formula.


Laxozome Max By EPG ~50mg
Laxozome Max By EPG ~50mg of Laxogenin

good stuff Review by Dave (Posted on 7/22/2019)

“You fell absolutely nothing when you take this….until you pack on the extra plates….it makes you stronger without a doubt! “



Laxogenin 100 By Hi-Tech Pharmaceuticals
Laxogenin 100 By Hi-Tech Pharmaceuticals 100mg of Laxogenin

BEST LAXOGENIN SUPPLEMENT OUT THERE Review by Teodor (Posted on 6/28/2019)

“I used to take Anogenin each day, but after researching more, the dosage was so low! Anogenin gives you 25mg per capsule. This product gives you 100mg per tablet and the technology for absorbing it much better. I have been taking between 200 and 400mg per day for about a month now and love it. Good pumps, good recovery and feel much fuller in the muscles. Hormone-free…great supplement from Hi-Tech.” 

Anogenin By Blackstone Labs
Anogenin By Blackstone Labs 25mg of Laxogenin

Has helped me so much Review by Lex (Posted on 8/5/2019)

“I couldn’t work out for a long time and lost a significant amount of muscle mass. But since I started using anogenin, it has been great for growth. My legs have never looked so good! Plus recovery has been much shorter! It is a great product!”



We mentioned a couple of stack options for laxogenin in the comparison section. But, some other products can be beneficial for muscle growth, while also being natural.

First starters, we have another Blackstone labs product, Halo Elite. Halo elite features a plant-derived androgen. Meaning it comes from plants but shares similarities to testosterone. Because it comes from plants it’s not hormonal and will not increase your testosterone.

So you shouldn’t look for this product as a test booster. But, it can increase protein synthesis. So combining Halo Elite with a laxogenin of your choice can be a great muscle building stack. Add-in epicatechin to help increase the fat loss too.

Moving forward with fat loss, you can stack laxogenin with your favorite fat burner. If you want to keep it stimulant-free you can stack it with Recomp-RX, CLA, L-Carnitine or another stimulant-free blend.

Wrapping It Up

This marks the end of our updated Laxogenin post. We hope you found the information helpful and of course if you have any questions, leave a comment below or send us an email! 

PLEASE NOTE: †The intention of the information provided is for reference only and we are in no way providing medical advice or instruction. The information provided in this post is based on anecdotal information and available studies/reviews. While it is our goal to maintain and display accurate information, we can’t guarantee it represents the latest formulation of the product or information. Therefore, if you have any concerns, please visit the manufacturer’s website. Also, the information above is not a representation of our views at Same Day Supplements. Rather, these are the views and information provided by manufacturers and users. Also, the Food and Drug Administration has not evaluated these statements. Finally, the intention of these products is not to diagnose, treat, cure or prevent any disease or illness