Best time to take them ? With or without food.

Best timing is when discomfort starts, since the formula is quick acting. The label directions are 2 tablets up to 3 times daily, not more than 6 tablets in 24 hours. There is no meal instruction, so it can be taken with or without food; if you notice stomach upset, take it with a snack and a full glass of water. Space doses across the day, for example morning, midday, and evening. Do not use if pregnant or nursing, and speak with a clinician if you use medications.