Mesomorph Pre Workout | Old VS New 2025 UPDATE (Review)

📖 Table of Contents

• What Is Mesomorph
• Original Mesomorph
• Mesomorph in 2020
• Mesomorph V3 VS V4
• Mesomorph Reviews
• Mesomorph Alternatives
• Where To Buy
• Side Effects And Warnings
• Disclaimer

We all want to be the biggest and strongest we can be. When it comes to getting into shape and working out, there are a lot of factors that go into it. Diet, training, and even supplementation play a part in how you look and perform. So, when it comes to improving our performance and getting the most out of every gym hit, it’s no surprise that we look for products to get us in the zone. That’s where pre workouts like Mesomorph come into play. In this post, we’ll be covering Mesomorph pre workout today, formula revisions, reviews, and what compares!  

Quick Facts

• Rating: ★★★★★ (5/5)
• Best For: Experienced lifters seeking high-energy, tunnel‑vision focus†
• Servings: 25
• Caffeine: ~300 mg per scoop
• Key Stimulant Blend: DMHA, Caffeine Anhydrous, Theobromine, Geranium Extract†
• Calories: 0
• Cost per Serving: ~$1.60

What Is Mesomorph?

Mesomorph Pre Workout has held its crown as one of the most iconic, high-stimulant pre-workouts since it hit the market in 2013. Whether you’ve been a loyal user since the DMAA days or you’re revisiting the formula in its latest 2025 version, one thing remains clear:

Mesomorph is not for the faint of heart—and it never has been.†

Through multiple reformulations, label updates, and regulatory tweaks, Mesomorph continues to deliver intense energy, clinical-strength dosing, and powerful pumps, earning it a lasting place in the “hardcore pre” hall of fame.†

The Original Mesomorph:

Even in its earliest release, Mesomorph was designed with experienced gym-goers in mind. Despite the use of a proprietary blend, the OG formula included full clinical doses of its key ingredients, which was rare for the time.

At the heart of Mesomorph’s effectiveness were its three signature complexes:

1. Synthenox-Carnosine / Nitric Oxide Complex

2. Mesoswell-Cell Volumizing ATP Matrix

3. Neuromorph-Neuro Energized Stimulant Matrix

Together, these provided a massive 12,870mg of active ingredients, split across 14 hand-picked compounds.

Worth noting: Despite multiple updates to Mesomorph over the years, two of these three complexes have remained virtually unchanged since 2013—a testament to their effectiveness. The only real evolution has occurred in the stimulant matrix.

Synthenox-Carnosine/Nitric Oxide Complex:

This pump-enhancing complex has stood the test of time—and for good reason. It contains:

• Beta-Alanine – Buffers lactic acid, delays fatigue†

• L-Citrulline DL-Malate – Boosts nitric oxide, enhances vascularity†

• Arginine Alpha-Ketoglutarate (AAKG) – Supports blood flow and nutrient delivery†

Together, these ingredients promote endurance and circulation, helping deliver that “skin-splitting pump” Mesomorph is known for.† (1,2,3)

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Mesoswell-Cell Volumizing ATP Matrix:

Next up is the hydration, strength, and cell-volumizing blend featuring:

• Di-Creatine Malate
• L-Taurine
• Creatine Nitrate
• Ascorbic Acid (Vitamin C)
• Creatinol-O-Phosphate
• Agmatine Sulfate

This blend supports intra-workout hydration, ATP production, and faster recovery. Creatine and taurine help improve strength and cellular volume, while vitamin C may lower cortisol, helping reduce muscle soreness.† (4,5,6,7,8,9,10,11)

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Neuromorph-Neuro Energized Stimulant Matrix:

This is where Mesomorph earned its reputation—and sparked controversy.

The OG stimulant complex contained:

• Glucuronolactone – Supports alertness†

• Methylxanthine Anhydrous (Caffeine) – Core stimulant†

• Theobromine – Smooth, long-lasting energy†

• Naringin – Enhances absorption and metabolic rate†

• Geranaburn™ (DMAA) – The infamous original stim, since replaced in newer versions†

This matrix was designed for mental clarity, tunnel-vision focus, and intense energy—often mimicked, rarely duplicated.† (12,13,14,15,16)

Mesomorph In 2020:

Before we break down the current 2025 formula, let’s rewind to a key point in Mesomorph’s evolution—Mesomorph V3, released in 2020. This version replaced the original DMAA-based stimulant blend with newer, still-potent ingredients. While many fans were skeptical at first, V3 still packed a serious punch in the gym. The Neuromorph Neuro Energized Stimulant Matrix was reduced slightly to 1,860mg (compared to the original 1,870mg), but its ingredient profile shifted significantly.†

In the updated V3 formula, this matrix featured:

• Senegalia Berlandieri Extract
• Phenylethylamine Alkaloids
• Theobromine
• Isopropylnorsynephrine HCl

Theobromine

Listed in the original formula as “3,7-Dihydro-3,7-Dimethyl-1H-Purine-2,6-Dione,” theobromine technically never left the formula—only its labeling changed.

This xanthine alkaloid, derived from cacao, functions similarly to caffeine but with longer-lasting effects.† It’s a:

• Mild stimulant†

• Mood elevator†

• Appetite suppressant†

In addition to increasing alertness and energy, it may also promote vasodilation, supporting better blood flow and performance.† (17)

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Geranaburn™ (DMAA)

The defining compound in the OG Mesomorph, Geranaburn™ is the trademarked form of DMAA (1,3-dimethylamylamine HCl)—a powerful central nervous system stimulant.†

DMAA works by:

• Increasing dopamine and noradrenaline activity†

• Producing rapid, intense bursts of energy†

• Enhancing focus and euphoria†

• Mimicking the stimulation curve of ephedrine and early Jack3d†

While no longer part of V3 due to regulatory changes, DMAA’s removal marked the biggest shift between the original and this updated version.†

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Senegalia Berlandieri Extract

A rising star in high-stim pre workouts and fat burners, Senegalia provides PEAs and other alkaloids that can: (18)

• Boost energy†

• Suppress appetite†

• Create a euphoric “tunnel focus” effect†

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Isopropylnorsynephrine HCl (Octopamine)

This next-gen synephrine analog helps: (19)

• Stimulate beta-3 adrenergic receptors†

• Increase thermogenesis†

• Inhibit glucose uptake in fat cells, encouraging fat oxidation and weight loss†

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Phenylethylamine

Found both in Senegalia and as a standalone compound, PEA is a naturally occurring mood-enhancing stimulant that supports:

• Mental clarity†

• Motivation and concentration†

• Endorphin release (your “feel-good” neurotransmitters)†

PEA is also one of the chemicals naturally found in chocolate, which is why it can promote a euphoric, uplifted feeling during intense training.†  (20,21)

Mesomorph V3 VS V4:

In November 2020, APS Nutrition introduced another major formula revision—marking the shift from Mesomorph V3 to Mesomorph V4, the version still in circulation as of 2025.

While the Nitric Oxide and ATP Matrix blends remained the same, the Neuromorph stimulant matrix saw three key ingredient swaps that dramatically altered the pre-workout’s profile.

The updated version now includes:

• 2-Aminoisoheptane HCl (DMHA)

• Geranium Extract (Stem & Leaves)

• Quebracho Blanco Extract

These replaced:

• Senegalia Berlandieri Extract

• Phenylethylamine Alkaloids (PEAs)

• Isopropylnorsynephrine HCl (Octopamine)

 

1. 2-Aminoisoheptane (DMHA)

The most notable change in V4 is the introduction of 2-Aminoisoheptane, commonly known as DMHA. Structurally similar to DMAA, DMHA is a powerful central nervous system stimulant that may: (22)

• Increase energy and alertness†

• Enhance mood and focus†

• Promote thermogenesis and appetite suppression†

DMHA is considered one of the closest legal alternatives to DMAA, and its inclusion brought back much of the energy and performance V3 users felt was missing.†

 You can read more about DMHA HERE.

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2. Geranium Extract (Stem & Leaves)

At first glance, this may raise some eyebrows—especially among longtime Mesomorph fans who associate Geranium Oil with the original DMAA formula.†

However, it’s important to clarify:

There is no DMAA in Mesomorph as of 2025.

The Geranium Extract used in the V4 formula is stripped of the alkaloids responsible for DMAA’s intense effects. While it may offer mild mood elevation or focus benefits, its stimulant properties are far weaker and less studied than purified DMAA or DMHA.† (23)

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3. Quebracho Blanco Extract

This is the wild card in V4. Derived from a South American tree, Quebracho Blanco Extract has limited research, but early sources suggest it may act as:

• A vasodilator, promoting increased blood flow†

• A mild aphrodisiac, with possible mood-enhancing effects†

Though not a heavy-hitter stimulant, it may complement the overall blend by improving vascularity and nitric oxide levels—helping you “feel” the pump more intensely.† (24)

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Overview:

What Flavors Are Available?

Mesomorph is known not just for potency, but for standout flavor. Most flavors mix well with minimal clumping or sediment. Below we have listed the flavors available…in order of ranking popularity.

1. Rocket Pop
2. Tropical Punch
3. Green Apple Candy
4. Pink Lemonade
5. Tutti Frutti
6. Snow Cone
7. Strawberry Kiwi
8. Grape
9. Watermelon
10. Carnival Cotton Candy
11. Pineapple

Mixability: Mixes best with 8–10 oz cold water. A few users report light foam or mild grit at the bottom with some flavors—common in high-stim powders.†

What To Expect With Mesomorph V4?

With all these additions accounted for, Mesomorph is still going to be a strong pre workout. However, unlike in the previous formula, you most likely won’t get that surge of energy. Based on these new additions, there will be a strong focus on this pre-workout, as well as mood enhancement.† 

The energy is still there, and we would definitely recommend you assess your tolerance before taking a full scoop. This version has more of a sustainable energy blend, meaning when you feel it, it’ll last. So far, based on our team’s experience, Mesomorph pre workout is still the King of Pre Workouts. But in 2025, customer reviews tend to be mixed. Some customers favor Mesomorph V3 with Senegalia over V4 with DMHA.†

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Stacking and Cycling Recommendations

• Cycling: Use Mesomorph for a maximum of 8 weeks, followed by a 4-week break to prevent tolerance build-up.†

• Stacking: Avoid combining with other stimulant-containing products within a few hours. For enhanced pumps without additional stimulants, consider stacking with a non-stimulant pump product (e.g., Glycerol products).†

Mesomorph Reviews:

And despite all the changes, we see Mesomorph holding onto its reign, and the customer reviews show that as well!

Pros

• High Energy and Focus: Users report intense energy and improved focus during workouts.†

• Effective Pump: The nitric oxide complex contributes to noticeable muscle pumps.†

• Variety of Flavors: Multiple flavor options cater to different taste preferences†

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Cons

• Potential Side Effects: Some users experience jitters or overstimulation due to potent stimulants like DMHA and Geranium Extract.†

• Taste Sensitivity: A minority find certain flavors less palatable.†

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Customer Review By Anthony: “Best pre-workout I have tried thus far, highly recommend!” Posted On 5/30/25

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 Customer Review by TJS: “Been taking this since 2021 as the main hitter every day up until summer 2024 where I added like 20 preworkouts into rotation. Mesomorph is still one of my favorites along with amp3d, although I really wish they would put the Senegalia back!!! V3 was forsure better than V4” Posted on 5/04/25

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Customer Review by Chase: “Love this pre workout. Order came quick too.” Posted on 2/16/25

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Customer Review by Michael: “I love the kick that it gives in energy. The taste is good as well. I have tried a few and all has been good..”  Posted on 11/26/24

Mesomorph Alternatives :

The last thing we’d want is for Mesomorph to disappear again. But if you’re here to look for a substitute for Mesomorph, we’ve got you covered.

• AMP3D Pre Workout
• Broken Arrow Pre Workout
• Super Pump Aggression Pre Workout
• Jack3d Pre Workout

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Mesomorph vs AMP3D Pre Workout

A high-stim alternative to Mesomorph, AMP3D Pre Workout features a fully disclosed label with clinically dosed ingredients across five categories: endurance, pump, power, energy, and focus. The stimulant blend combines both DMHA and caffeine for sustained energy. AMP3D shares the following ingredients with Mesomorph:

• Beta Alanine
• L-Citrulline
• Taurine
• Creatine Monohydrate
• Agmatine
• Caffeine Anhydrous
• 2-Aminoisoheptane (DMHA)
• Theobromine

AMP3D also includes additional ingredients that are not found in Mesomorph:

• L-Citrulline Silicate (Nitro-Rx)
• L-Arginine HCL
• S-(2-boronethyl)-L-cysteine HCL (BEC)
• Red Wine Extract (30% Glycerol)
• Adenosine Triphosphate (ATP)
• Phenylethylamine HCL
• Yohimbine Extract

These additions enhance AMP3D’s nitric oxide output, hydration, mood, and thermogenic potential. The combination of DMHA, caffeine, theobromine, and PEA makes it one of the few pre-workouts that closely replicates the intense focus and energy that made Mesomorph popular, without using DMAA. (25, 26, 27)

AMP3D Review By Tommy: “Coming back to this review as it’s grown on me, this is definitely a good solid hitter. Nice pumps and keeps steady aggression, I like keeping this one in the rotation. Sour gummy is the best tasting preworkout I’ve had so far, pretty smooth overall. I stack this with either HydroMax or N’Groge Xtreme and a half scoop of Juicy Pumps by Quality Vitamins (not sold on this site). Pumps and endurance are insane with all of these stacked!” Posted on 10/08/24

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Mesomorph vs Broken Arrow Pre Workout:

Our next Mesomorph alternative is a high stimulant pre workout that features a DMAA-Like Stimulant, Citrus Aurantium Extract (Synephrine). Broken Arrow by Repp Sports, similarly to Mesomorph, has had several formula revisions (Read more about the original Broken Arrow Here). But in its current formula, Broken Arrow features ~14 grams of active ingredients. Of these ingredients, only five are shared with Mesomorph:

• L-Citrulline Malate
• Beta Alanine
• L-Taurine
• Caffeine
• Theobroma Cacao Extract (Theobromine)

This leaves six ingredients that are different:

• Sodium
• Betaine Anhydrous
• L-Tyrosine
• Citra-Fuze Stim Blend
• Alpha GPC
• Black Pepper Extract

5 Of the remaining six ingredients, five are identical to Frankenstein, and what makes Broken Arrow unique is CitraFuze Stimulant Blend. This blend of citrus-based stimulants contains synephrine, an ingredient more common in fat burners. Synephrine is a strong stimulant with thermogenic and mood-boosting properties. In a pre workout, that can translate to enhanced focus and increased sweat/water weight loss. (28)

Broken Arrow Review By Chet: “Good energy and pumps. Great price too. Hail Storm is my favorite flavor so far, going to try Galaxy Burst next time.” Posted on 6/26/24

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Mesomorph vs Super Pump Aggression Pre Workout:

Our third comparison is pretty different from Mesomorph, but it’s all the levels of intensity we look for in the gym. Super Pump Aggression features a fully disclosed label that includes 18 grams of active ingredients. You can read more about Super Pump and Super Pump Aggression HERE.

Of these ingredients, five are shared:

• L-Citrulline
• Beta Alanine
• Agmatine Sulfate
• Caffeine Anhydrous
• Theobromine

Which leaves eight ingredients unique to Super Pump Aggression:

• Betaine Anhydrous
• L-Tyrosine
• PEA
• Choline Bitartrate
• DMAE
• Black Pepper Extract
• Rauwolfia Vomitoria Extract
• Huperzia Serrata Extract

3 of these ingredients are shared with the other alternatives: Betaine, L-Tyrosine, and Black Pepper Extract. The remaining five ingredients are going to aid in supporting Super Pump Aggression’s focus complex. (29, 30,31,32,33,34)

Super Pump Aggression Review By Hank: “I use this product when I’m doing heavy lifting because it has that Kick I need to squeeze out those last couple of reps!!” Posted on 1/2/24

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Mesomorph vs Jack3d Pre Workout:

Our last Mesomorph comparison is with another infamous OG pre workout Jack3d. Like Mesomorph, Jack3d previously featured DMAA. But Jack3d V2 now features a proprietary blend with ~4.2 grams of active ingredients per scoop and about 135mg of Caffeine per scoop. Between Mesomorph and Jack3d, six ingredients are shared:

• Arginine Alpha-Ketoglutarate
• Creatine Monohydrate
• Beta Alanine
• 2-Aminoisoheptane HCL
• Geranium Extract (stem and leaves)
• Caffeine

This leaves two ingredients unique to Jack3d:

• Yohimbe Extract
• Schisandra Chinensis

Yohimbe is a common ingredient in fat burners due to its thermogenic properties and is similar to Rauwolfia Vomitoria. Because of their similarities, they may function in the same way. This can mean promoting energy, focus, and fat loss. (35,36) Whereas Schisandra Chinensis extract may be useful as an adaptogen and performance enhancer (37, 38).

Jack3d Pre Workout Review By Tyler: “This stuff is insane. Everyone please folllow guidelines when. You take this and do not start out with the maximum dose. Geez I think half a scoop would of even been enough”  Posted on 4/27/24

Which Should You Try?

Not all pre workouts hit the same—and choosing your ideal alternative depends on your training goals, stim tolerance, and desired effects.
Here’s a quick breakdown to help guide your pick:

• 💥 Want the closest feel to OG Mesomorph with DMHA?
  Try AMP3D — combines DMHA, caffeine, PEA, and nitric oxide support for sustained energy, strong pumps, and mood enhancement.†
• 🔥 Looking for intense energy with added thermogenic effects?
  Go with Broken Arrow — features synephrine (from Citrus Aurantium) for a sweat-inducing, fat-burning edge and a powerful stim blend.†
• 🎯 Need extreme focus and mental drive for heavy lifts?
  Choose Super Pump Aggression — formulated with choline, DMAE, and huperzine for razor-sharp focus and aggression in the gym.†
• ⚡ Prefer a low-dose, OG-style stim blend with a fast hit?
  Check out Jack3d — a proprietary blend with classic feel, DMHA, and a shorter ingredient list ideal for quick sessions.†

Still unsure? You can always contact our team for personalized recommendations or try stacking a pump product with your favorite stim for custom results.†

Where To Buy Mesomorph Pre Workout?

Looking to get started—or ready for your next round? You can order Mesomorph V4 Pre‑Workout directly from SameDaySupplements.com, where it’s in stock and ready to ship fast.

• 🚚 Ships same day (M–F before 3 PM EST)
• ✅ Trusted U.S. retailer with verified customer reviews
• 💥 Bundle deals available

Whether you’re after hardcore energy or dialed‑in focus, we’ve got your pre‑workout—locked and loaded.†

Wrapping Up!

This wraps up the end of our review and comparison of Mesomorph Pre Workout. Thank you for reading! And as always, if there was something that wasn’t clear, another question you might have, or if you have another idea for a blog, Email Us!

Looking for more to read?

Check out some of our other blogs!

• Are You Mesomorph?
• GAT Nitraflex Pre workout Review
• Condense Pre-Workout Review Purus Labs 
• Dust V2 by Blackstone Labs Review Pre-Workout

Side Effects And Warnings:

Read the entire label before taking this product. As with any supplement, check with your physician before use. Do not use this product if you have any current or previous medical condition of any kind. Such conditions may include, but are not limited to, the following:

• High or low blood pressure
• Stroke
• Arrhythmia
• Palpitations
• Any heart, thyroid, or liver condition
• Seizures
• Anxiety or depression
• Prostate enlargement or inflammation

Do not use it if you are nursing or pregnant. Do not use it if you are taking an MAOI. If any adverse symptoms occur, stop use immediately and consult a physician. Keep out of reach of children.

Disclaimer: